Ultrastructural Analysis of In Vivo Hypoglycemiant Effect of Two Polyoxometalates in Rats with Streptozotocin-Induced Diabetes

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Ştefana BâliciHorea Matei

Abstract

Two polyoxometalates (POMs), synthesized through a self-assembling method, were used in the treatment of streptozotocin (STZ)-induced diabetic rats. One of these nanocompounds [tris(vanadyl)-substituted tungsto-antimonate(III)-anions—POM1] was previously described in the literature, whereas the second [tris-butyltin-21-tungsto-9-antimonate(III)-anions—POM2], was prepared by us based on our original formula. In rats with STZ-induced diabetes treated with POMs (up to a cumulative dose of 4 mg/kg bodyweight at the end of the treatments), statistically significant reduced levels of blood glucose were measured after 3 weeks, as compared with the diabetic control groups (DCGs). Ultrastructural analysis of pancreatic β-cells (including the mean diameter of secretory vesicles and of their insulin granules) in the treated diabetic rats proved the POMs contribute to limitation of cellular degeneration triggered by STZ, as well as to the presence of increased amounts of insulin-containing vesicles as compared with the DCG. The two POMs also showed hepatoprotective properties when ultrastructural aspects of hepatocytes in the experimental groups of rats were studied. Based on our in vivo studies, we concluded that the two POMs tested achie...Continue Reading

References

Sep 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S L ErlandsenL S Van Orden
Oct 1, 1990·Metabolism: Clinical and Experimental·E FerranniniG Van de Werve
Apr 1, 1973·Diabetologia·P M Dean
Oct 29, 1982·Biochemical and Biophysical Research Communications·C Cibert, C Jasmin
Aug 1, 1994·Journal of the American Dietetic Association·B F Harland, B A Harden-Williams
Nov 1, 1996·Antiviral Research·L NiF D Boudinot
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·O WiserD Atlas
Apr 9, 1999·Acta Paediatrica. Supplement·K KidaK Nakamura
Jun 25, 1999·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·V BadmaevM Majeed
Jun 6, 2000·Molecular and Cellular Biochemistry·A K Srivastava
Aug 10, 2000·The Journal of Biological Chemistry·S VaulontA Kahn
Nov 15, 2000·Canadian Journal of Physiology and Pharmacology·M C CamJ H McNeill
Apr 20, 2001·Journal of Medicinal Chemistry·H van De WaterbeemdD K Walker
Feb 20, 2002·Chemical Reviews·Jeffrey T. RhuleRaymond F. Schinazi
Sep 26, 2002·Biological Trace Element Research·José L Domingo
May 23, 2003·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniel A BarrioSusana B Etcheverry
Jul 25, 2003·Diabetologia·P Rorsman, E Renström
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Bernold Hasenknopf
Nov 11, 2005·American Journal of Therapeutics·Ji-Won Yoon, Hee-Sook Jun
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick E MacDonaldPatrik Rorsman
Oct 24, 2006·Journal of Inorganic Biochemistry·Katherine H Thompson, Chris Orvig
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Nov 1, 2007·International Journal of Andrology·C MallidisR A Browne
May 17, 2008·Biochemical Society Transactions·Sigurd Lenzen
Jan 2, 2009·Diabetes Research and Clinical Practice·Hisafumi YasudaMasao Nagata
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·K LemaireF C Schuit
Oct 23, 2010·Ecotoxicology and Environmental Safety·Nikolay Strigul
Nov 12, 2010·Trends in Endocrinology and Metabolism : TEM·Renaud DesgrazPedro L Herrera

❮ Previous
Next ❯

Citations

Aug 28, 2019·Current Medicinal Chemistry·Mirjana B ČolovićDanijela Z Krstić
Oct 24, 2018·Biological Trace Element Research·Samuel TreviñoEnrique González-Vergara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis