PMID: 9527543Apr 4, 1998Paper

Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery

The Journal of Comparative Neurology
R E Coggeshall, S M Carlton

Abstract

The present study determines the proportions of unmyelinated cutaneous axons at the dermal-epidermal junction in glabrous skin and of myelinated and unmyelinated axons in the sural and medial plantar nerves that immunostain for subunits of the ionotropic glutamate receptors. Approximately 20% of the unmyelinated cutaneous axon profiles at the dermal-epidermal junction immunostain for either N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainate receptor subunits. These findings are consistent with previous observations that NMDA and non-NMDA antagonists ameliorate nociceptive behaviors that result from noxious peripheral stimulation. In the sural nerve, where the large majority of myelinated fibers are sensory, approximately half of the myelinated axon profiles immunostain for the NMDA receptor 1 (R1) subunit, 28% immunostain for the glutamate receptor 1 (GluR1) AMPA subunit, and 11% for the GluR5,6,7 kainate subunits. Even higher proportions immunostain for these receptors in the medial plantar nerve, a mixed sensory and motor nerve. In the sural nerve, 20% of the unmyelinated axon profiles immunostain for NMDAR1 and only 7% label for GluR1 or GluR5,6,7. Because the sural nerve...Continue Reading

Associated Clinical Trials

Citations

Jun 20, 2001·Journal of Virology·R L Thompson, N M Sawtell
Nov 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Banani BanerjeeReza Shaker
Oct 1, 2013·European Journal of Applied Physiology·J HadréviF Hellström
Mar 24, 2012·Autoimmunity Reviews·Harry E PeeryWarren G Foster
Feb 8, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Min K ParkDong K Ahn
May 15, 2007·Medical Hypotheses·Erle C H Lim, Raymond C S Seet
Jun 5, 2007·Brain Research Reviews·Ilaria RoglioRoberto Cosimo Melcangi
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·Håkan Alfredson
Nov 19, 2003·The European Journal of Neuroscience·Vivian SathianathanIstvan Nagy
Sep 5, 2006·Alimentary Pharmacology & Therapeutics·E A MayerS Bradesi
Feb 5, 2010·British Journal of Pharmacology·Francis F Y Lam, Ethel S K Ng
Sep 18, 2010·Head & Neck·Helga Susanne HaasAnton Sadjak
Apr 2, 2016·European Journal of Pharmacology·Jesper T AndreasenDarryl S Pickering
Feb 14, 2016·Muscle & Nerve·Pia Crone ChristensenPeter K Stys
Jun 10, 2016·Basic & Clinical Pharmacology & Toxicology·Viviana La RoccaReinaldo Nóbrega de Almeida
Apr 1, 2015·Steroids·Silvia GiattiRoberto C Melcangi
Sep 2, 2006·The Journal of Physiology·James A SlatteryL Ashley Blackshaw
Mar 13, 2021·Frontiers in Pharmacology·Clayton CulpSalahadin Abdi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.