Ultrastructural analysis of the central terminals of primary sensory neurones labelled by transganglionic transport of bandeiraea simplicifolia I-isolectin B4

Neuroscience
M B Gerke, M B Plenderleith

Abstract

In this study the ultrastructural appearance of primary sensory neurones labelled by the injection of the plant lectin Bandeiraea simplicifolia I-isolectin B(4) (BSI-B(4)) into a peripheral nerve has been examined in the rat. Electron microscopy of the somata of retrogradely labelled neurones showed the lectin to be associated with the inner surface of cytoplasmic vesicles, supporting the premise that the uptake of BSI-B(4) into sensory neurones is by the process of receptor-mediated endocytosis. Light and electron microscopic analysis of the spinal cord revealed transganglionically transported lectin in unmyelinated axons in the dorsolateral funiculus and axon terminals concentrated mainly within lamina II of the dorsal horn. Detailed analysis of 1377 of these axon terminals revealed that the majority were glomerular in shape and surrounded by up to 14 other unlabelled profiles. These findings suggest that primary sensory neurones which transganglionically transport BSI-B(4) have a synaptic ultrastructure similar to that which has been previously reported for unmyelinated primary sensory neurones. Moreover, it appears that the axon terminals of these neurones are subjected to extensive modulation. Examination of the vesicle co...Continue Reading

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Citations

Oct 31, 2009·Molecular Neurobiology·Max Larsson
Sep 8, 2010·Neuroscience Letters·Kentaro OnoKiyotoshi Inenaga
Feb 11, 2005·Journal of the Peripheral Nervous System : JPNS·Peter D J ThorntonMark B Plenderleith
Jul 29, 2006·The Journal of Comparative Neurology·Jinlian LiNoboru Mizuno
Jun 15, 2012·The European Journal of Neuroscience·Annabelle Reaux-Le GoazigoStéphane Melik Parsadaniantz
Nov 18, 2006·Neuroscience·V StaikopoulosE A Jennings
Jun 6, 2009·The American Journal of Gastroenterology·Ai-Hua QianYao-Zong Yuan

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