Ultrastructural analysis of ventrolateral periaqueductal gray projections to the A7 catecholamine cell group

Neuroscience
D BajicH K Proudfit

Abstract

Stimulation of neurons in the ventrolateral periaqueductal gray produces antinociception that is mediated in part by pontine noradrenergic neurons. Previous light microscopic analysis provided suggestive evidence for a direct projection from neurons in the ventrolateral periaqueductal gray to noradrenergic neurons in the A7 cell group that innervate the spinal cord dorsal horn. Therefore, the present ultrastructural study used anterograde tracing combined with tyrosine hydroxylase immunoreactivity to provide definitive evidence that neurons in the ventrolateral periaqueductal gray form synapses with the somata and dendrites of noradrenergic neurons of the A7 cell group. Injections of the anterograde tracers biotinylated dextran amine or Phaseolus vulgaris leucoagglutinin into the ventrolateral periaqueductal gray of Sasco Sprague-Dawley rats yielded a dense innervation in the region of the lateral pons containing the A7 cell group. Electron microscopic analysis of anterogradely labeled terminals (n=401) in the region of the A7 cell group indicated that approximately 10% of these formed plasmalemmal appositions to tyrosine hydroxylase-immunoreactive dendrites with no intervening astrocytic processes. About 23% of these were asym...Continue Reading

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Citations

Nov 15, 2011·Brain Structure & Function·Tamás VargaArpád Dobolyi
Feb 1, 2003·European Journal of Pharmacology·Umit Kazim OzdoğanMika Scheinin
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
May 30, 2002·Progress in Neurobiology·Mark J Millan
May 26, 2009·Molecular and Cellular Neurosciences·Ming-Yuan MinHsiu-Wen Yang
Apr 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ming-Yuan MinHsiu-Wen Yang
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Apr 3, 2008·The Journal of Comparative Neurology·Jun LuClifford B Saper
Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Mar 25, 2011·Journal of Neurophysiology·Yeechan WuMing-Yuan Min

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