PMID: 3746343Sep 1, 1986Paper

Ultrastructural and biochemical characterization of autonomic neuropathy in rats with chronic streptozotocin diabetes

Journal of Neuropathology and Experimental Neurology
R E Schmidt, S B Plurad

Abstract

Alterations in the extrinsic innervation of the alimentary tract and in various sympathetic autonomic ganglia were examined using quantitative ultrastructural and biochemical methods in streptozotocin diabetic rats maintained without treatment for 9-15 months. Ileal mesenteric nerves of 13-15 month diabetics showed the characteristic alterations of neuroaxonal dystrophy qualitatively similar to changes seen in this system in animals which were diabetic for shorter durations. Dystrophic axonopathy was not accompanied by significant axonal loss or atrophy. Dystrophic axons, presumably involving presynaptic elements, also were increased in frequency in the superior mesenteric ganglia, but not in the superior cervical ganglia, of animals diabetic for various durations. In addition, the superior mesenteric ganglia of diabetic animals contained an increased number of postsynaptic dendritic processes which were dilated by unusual tubular profiles. These ganglionic alterations were not accompanied by changes in the activity of the presynaptic cholinergic marker enzyme, choline acetyltransferase. The activity of the noradrenergic marker enzyme, dopamine-beta-hydroxylase, was unaltered in diabetic superior mesenteric ganglia compared to ...Continue Reading

Citations

May 1, 1991·Journal of Neurocytology·S S Tay, W C Wong
Dec 1, 1996·Journal of Neurocytology·R E Schmidt
Sep 1, 1995·Journal of the Neurological Sciences·D E WolfeR J Desnick
Mar 4, 1998·Diabetes Research and Clinical Practice·M S BitarR J Waldbillig
Jul 18, 2001·Journal of Diabetes and Its Complications·N E Cameron, M A Cotter
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Adriana Werner BalbinottBeatriz D'Agord Schaan
Jan 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·R E Schmidt
Oct 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P K Thomas
Apr 18, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Zhonghai WeiLiangrong Zheng
Dec 5, 2008·Autonomic Neuroscience : Basic & Clinical·Katia De AngelisMariana Morris
Nov 7, 1999·The American Journal of Pathology·R E SchmidtM S Miller
Sep 10, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K De AngelisM C Irigoyen
Feb 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B D SchaanM C Irigoyen
Nov 24, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B D SchaanM C Irigoyen
Jan 1, 1993·Current Eye Research·H Li, P Grimes
Jan 28, 2017·Scientific Reports·Ying LiuMohamed H Farah
Dec 13, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtAnders A F Sima
Jan 5, 2002·Journal of Neuropathology and Experimental Neurology·R E SchmidtY Ido
Apr 29, 1999·Brain Pathology·D W Zochodne

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