PMID: 2499093Jan 1, 1989Paper

Ultrastructural and electron immunohistochemical features of medullary thyroid carcinoma

Virchows Archiv. A, Pathological Anatomy and Histopathology
R HolmJ V Johannessen

Abstract

An ultrastructural study, both morphological and immunohistochemical, has been carried out on eight thyroglobulin-positive and nine thyroglobulin-negative medullary carcinomas of the thyroid. The morphometric analysis of granule size showed that all tumours contained cells with small granules and cells with medium size granules, whereas eight tumours had additional cells with large granules. The small granules had an electron dense core, while the medium and large sized granules were both pale-cored and dense-cored. The cells with small, medium or large secretory granules were all immunoreactive for calcitonin and CGRP. No ultrastructural differences were observed between thyroglobulin-positive and thyroglobulin-negative cases of medullary carcinoma of the thyroid.

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Citations

Jun 29, 2004·Micron : the International Research and Review Journal for Microscopy·Sverre-Henning Brorson
Feb 13, 2001·Micron : the International Research and Review Journal for Microscopy·S H Brorson, G H Nguyen
Aug 11, 2000·Micron : the International Research and Review Journal for Microscopy·S H BrorsonI K Woxen
Feb 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S H BrorsonF Skjørten
Dec 10, 2008·Journal of Immunological Methods·Fabio D'AmicoFranca Stivala
May 29, 2008·Operative Dentistry·Francesca MonticelliMarco Ferrari
Jan 1, 1994·Ultrastructural Pathology·R A Erlandson, J M Nesland

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