Ultrastructural and electrophysiologic changes of rat cochlea after irradiation

The Laryngoscope
Halit AkmansuIlkan Tatar

Abstract

To determine the acute and subacute cochlear effects of sublethal total body irradiation. The study was designed prospectively as a Sprague-Dawley (SD) rat model with otoacoustic emission measurement. Ten rats and 20 ears were included in the study. Distortion product otoacoustic emission (DPOAE) measurements were performed under ketamine anesthesia before and 1 to 8 weeks after sublethal dose total body irradiation. Eight and six rats survived at the first and eighth week measurements, respectively. The frequency bandwidth was set to 1,067 Hz (referenced to f1) - 9,512 Hz (referenced to f2) (2f1 - f2 = 832 - 6,076 Hz) and eight points were sampled per octave, but low-frequency (<2,549 Hz [referenced to 2f1 - f2]) results were not included in the analysis. Averages were obtained at each frequency, and statistical analysis was performed to compare the pre-and postradiation values. Then, three of the rats were killed for transient electron microscopy (TEM) of the temporal bones. The posttreatment DPOAEs at almost all frequencies showed a trend toward decline at both the first and eighth weeks, but significant reduction was only detected at 3,600 and 3,961 Hz (referenced to 2f1 - f2) in the first week. TEM of the cochlea revealed ...Continue Reading

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Citations

Sep 25, 2007·The Journal of Laryngology and Otology·C GocerS H Akmansu
Jul 18, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chen YangJin-Hao Peng
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Gary V WalkerAnita Mahajan
Jul 31, 2014·The Laryngoscope·Mario A Mujica-MotaSam J Daniel
May 23, 2015·The Laryngoscope·Isil KaraerAyse Nuransoy
Jun 14, 2015·Medical Oncology·Susan CheraghiSeied Rabi Mehdi Mahdavi
Jul 28, 2016·Head & Neck·Elton M LambertPaul W Gidley
Nov 30, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christine T DinhThomas Van De Water
Oct 3, 2017·International Journal of Radiation Biology·Susan CheraghiSeied Rabi Mahdavi
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Seied Rabi MahdaviSusan Cheraghi

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