PMID: 11324715Apr 28, 2001Paper

Ultrastructural and functional changes in the jejunal epithelium of spontaneously hypertensive rats

Life Sciences
I Sánchez-AguayoC M Vázquez

Abstract

Ultrastructural studies on the epithelium, sugar transport and immunocytochemistry of Na+-glucose cotransporter (SGLT1) were carried out in the jejunum of Spontaneously Hypertensive Rats (SHR) and their normotensive genetic control, Wistar-Kyoto (WKY) rats. Electron microscopy studies showed a regular brush-border membrane in the jejunal enterocytes of WKY rats, with colloidal gold particles, representing SGLTI, localized at the microvilli of the absorptive epithelial cells. However, a patchy loss of microvilli was detected in the jejunal sections from SHR, with no presence of colloidal gold particles, indicating the absence of the SGLT1 protein. Most adjacent microvilli were normal in size like those found in WKY rats, and SGLT1 labeling was observed. All these changes were accompanied by a reduction in Na+-dependent D-glucose and D-galactose uptakes in the jejunal BBMVs isolated from SHR, when compared to WKY rats. We conclude that ultrastructural changes were paralleled by modifications in the sugar transport and in the localization of SGLT1 in the jejunal epithelium of SHR.

Citations

Oct 1, 2004·The Journal of Membrane Biology·A MateC M Vázquez
May 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alfonso MateJoana M Planas
Jun 27, 2019·Current Hypertension Reports·Masami Tanaka, Hiroshi Itoh
Mar 30, 2017·Current Hypertension Reports·Shiqiang XiongZhiming Zhu

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