Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages.

Infection and Immunity
D R Stevens, J E Moulton

Abstract

Trypanosome-activated mouse peritoneal macrophages phagocytized and digested Trypanosoma brucei in vitro and in vivo, but in the absence of specific antiserum and complement the degree of phagocytosis was minimal. Ultrastructurally, the parasites attached to the macrophage by their flagella, and ingestion proceeded flagellum first. Once ingested, T. brucei was degraded, presumably due to fusion of the parasite-containing phagosome with lysosomes. Contrariwise, normal mouse peritoneal macrophages displayed negligible ability to ingest T. brucei, even in the presence of specific antiserum and complement. During trypanosomiasis in deer mice (Peromyscus maniculatus), the development of hypergammaglobulinemia correlated with enhanced phagocytosis of T. brucei by macrophages, but only at early post-inoculation days (PID 5 to 15). Complement lysis of trypanosomes was not identified in these experiments. Between PID 20 to 30, antiserum and complement either had no phagocytosis-promoting ability or depressed the phagocytosis of T. brucei by macrophages. These results indicate that both specific antibody and complement contribute to the ingestion of T. brucei by activated macrophages, but that parasite antigenic variation effectively abr...Continue Reading

References

Feb 10, 1977·Nature·A N Jayawardena, B H Waksman
Jun 1, 1976·The Journal of Experimental Medicine·N Nogueira, Z Cohn
Jun 1, 1977·Experimental Parasitology·T Takayanagi, Y Nakatake
May 1, 1977·Infection and Immunity·J A Jarvinen, A P Dalmasso
Apr 15, 1976·Experientia·M Hommel, E Robertson
Nov 1, 1972·The American Journal of Tropical Medicine and Hygiene·H J Akiyama, N K McQuillen
Aug 1, 1974·Experimental Parasitology·T TakayanagiG L Enriquez
Nov 1, 1967·The Journal of protozoology·H C Miller, D W Twohy
Dec 1, 1971·Experimental Parasitology·C L Greenblatt, E Tyroler
Jan 1, 1970·Transactions of the Royal Society of Tropical Medicine and Hygiene·P F Boreham
Sep 1, 1960·Experimental Parasitology·D E LANGE, M G LYSENKO
Dec 1, 1963·Experimental Parasitology·M P CUNNINGHAMW A WEBBER
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

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Citations

Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M Blackwell, J Alexander
Sep 6, 2008·The Journal of Veterinary Medical Science·Boniface NamangalaNoboru Inoue
Jan 26, 2011·Parasite Immunology·B Namangala
Jan 31, 2007·Infection and Immunity·Boniface NamangalaNoboru Inoue
Dec 12, 2019·Frontiers in Immunology·Chukwunonso Onyilagha, Jude Ezeh Uzonna
Apr 1, 1981·International Journal for Parasitology·R M Cook
Oct 1, 1992·Infection and Immunity·M G RittigG R Burmester
Aug 26, 1998·Infection and Immunity·M G RittigC Bogdan
Sep 16, 2021·PLoS Pathogens·Henrique MachadoLuisa M Figueiredo

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African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

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