PMID: 6989863Apr 1, 1980Paper

Ultrastructural and immunological findings in Graves' disease with pretibial myxedema

Journal of Cutaneous Pathology
K KonradH Pehamberger

Abstract

This is a report on a 67-year-old female patient with Graves' disease and extensive pretibial myxedema. Linear IgM deposits were observed in the basement membrane zone by direct immunofluorescence. These deposits were found, by immunoelectron microscopy, to be haphazardly distributed in the uppermost dermis without any correlation to preexisting structures. An amorphous material that coated not only the surface of fibroblasts and collagen bundles but was also present within the dilated endoplasmic reticulum of the fibroblasts was the predominating pathological finding at the ultrastructural level. Mast cells were morphologically normal. These results support previous in vivo and recent in vitro findings indicating that the fibroblast plays a major role in the pathogenesis of pretibial myxedema.

References

Jul 1, 1978·The Journal of Investigative Dermatology·H S CheungM E Nimni
Dec 1, 1978·Journal of Cutaneous Pathology·H PehambergerK Holubar
Jun 1, 1976·The Journal of Investigative Dermatology·H HönigsmannK Wolff
Aug 1, 1973·The Journal of Clinical Investigation·M Landry, W M Sams
Oct 1, 1970·Journal of Clinical Pathology·T E Feltkamp, J H Boode
Jan 1, 1967·Archiv für klinische und experimentelle Dermatologie·G W KortingG Müller

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Citations

Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·R A MetcalfeA P Weetman
Dec 18, 2010·Thyroid : Official Journal of the American Thyroid Association·Aimin Deng, Dandan Song
Mar 21, 1998·The American Journal of Dermatopathology·M F AlvesL C Porto
Oct 1, 1991·Journal of Cutaneous Pathology·H J AhóV K Hopsu-Havu
Aug 1, 1985·The American Journal of the Medical Sciences·S P SinghB Yoon
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Vahab Fatourechi
Sep 1, 1995·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·P SauerR R Mahmarian
Mar 16, 2012·International Journal of Dermatology·Paul MadajAndrew G Gianoukakis
Jan 31, 2018·Arthritis Care & Research·Liudmila Kastsianok, Prabha Ranganathan
Feb 1, 1996·Thyroid : Official Journal of the American Thyroid Association·S R PeaceyA P Weetman
Apr 1, 1984·Journal of Cutaneous Pathology·M IshiiT Hamada
Nov 1, 1989·Journal of Endocrinological Investigation·F AkasuT Onaya
Oct 6, 2015·Journal of Cutaneous Pathology·Kinga Cristina SlavescuAdrian Baican

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