Ultrastructural aspect of myocarditis: its relevance for the diagnosis

Ultrastructural Pathology
J MilinD Zivkov-Saponja

Abstract

The Dallas consensus was used to reveal active or borderline inflammatory loci by light microscopy (LM). When lymphocyte-cardiocyte interaction was observed by electron microscopy (EM), the deleterious or dormant pattern of inflammatory process was recognized. The first was determined by lymphocytes that adhered to cardiocytes, next to necrotic cardiocytes or admixed with debris. The second was marked by scattered lymphocytes between preserved cardiocytes and the absence of lymphocytes adhered to cardiocytes and necrotic cardiocytes. The deleterious pattern of the inflammatory process (EM) commonly supplemented the active appearance of inflammatory loci (LM). In contrast, the borderline outlook of the LM completed either the deleterious or dormant pattern of the EM. This discrepancy was related to the restricted resolution of LM, which might hide the actual stage of the disease. The diagnosis of myocarditis was founded on mutual LM and EM observations. The active or borderline appearance of LM of the deleterious pattern (EM) was considered indicative for the active stage of myocarditis. The borderline outlook of the LM of the dormant pattern of the EM was admitted to indicate either the healing phase of the disease with lymphoc...Continue Reading

References

Dec 1, 1991·Journal of the American College of Cardiology·E B LiebermanK L Baughman
Jun 1, 1987·Human Pathology·H T Aretz
Jan 1, 1985·Heart and Vessels. Supplement·M E Billingham
Jan 1, 1985·Annual Review of Immunology·P A Henkart
Feb 1, 1994·Circulation Research·T A MartinoM J Sole

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