Ultrastructural aspects of acetylcholine receptor turnover at the normal end-plate and in autoimmune myasthenia gravis

Journal of Neuropathology and Experimental Neurology
G FumagalliJ M Lindstrom

Abstract

Acetylcholine receptor (AChR) deficiency at the myasthenic end-plate has been attributed to complement-mediated lysis of the junctional folds and to increased fractional degradation rate of AChR cross-linked by myasthenic immunoglobulin. This paper addresses the manner in which AChR is internalized and degraded at the normal end-plate and provides morphologic evidence for accelerated AChR degradation at the end-plate of rats with experimental autoimmune myasthenia gravis (EAMG). We sequentially traced the fate of end-plate AChR labeled in vivo with intramuscularly-injected peroxidase-alpha-bungarotoxin (PBGT) in control rats and rats with chronic EAMG. At both control and EAMG end-plates, AChR is internalized by endocytosis. The endocytosed vesicles containing AChR are transferred into the lysosomal compartment which extends from the junctional folds into the junctional sarcoplasm. Regardless of whether the initial intensity of the reaction for AChR at the EAMG end-plate appeared normal or reduced. AChR disappeared more rapidly from the EAMG than from the control end-plates. Despite the accelerated fractional turnover rate of end-plate AChR in EAMG, the postsynaptic membrane surface which could be labeled with PBGT for AChR rem...Continue Reading

Citations

Aug 24, 1999·Journal of Cellular Physiology·R Xu, M M Salpeter
Jan 1, 1982·Springer Seminars in Immunopathology·M E Seybold, J M Lindstrom
Mar 1, 1990·Journal of the Neurological Sciences·J H WokkeG J Leppink
Aug 16, 2015·Journal of Muscle Research and Cell Motility·Siegfried StrackRüdiger Rudolf
Jan 1, 1997·Molecular and Cellular Neurosciences·W D PhillipsP G Noakes
Feb 16, 2019·Muscle & Nerve·Srikanth MuppidiUNKNOWN Regain Study Group
Nov 30, 1999·Science·M M Salpeter
Jan 30, 2018·Annals of the New York Academy of Sciences·Min YanLin Mei
Feb 7, 2021·Archives of Biochemistry and Biophysics·Mariela L Paz, Francisco J Barrantes
Feb 13, 2021·Cells·Isabel Martinez-Pena Y Valenzuela, Mohammed Akaaboune
May 28, 2021·Annals of Clinical and Translational Neurology·James F HowardUNKNOWN REGAIN Study Group
Jan 1, 1984·Progress in Neurobiology·L Elfman
Nov 1, 1994·Survey of Ophthalmology·D A WeinbergT L Vollmer
Nov 1, 1984·Annals of Neurology·A G Engel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.