PMID: 8584271Nov 10, 1995Paper

Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells

Neuroscience Letters
S R SesackD A Lewis

Abstract

Dopamine terminals in the monkey prefrontal cortex (PFC) synaptically target the distal dendrites of both pyramidal cells and GABA interneurons. We sought to determine whether the latter input includes the innervation of interneurons that utilize calretinin (CalR) as a calcium-binding protein. Sections through prefrontal area 9 of cynomolgus monkeys were processed by immunoperoxidase for tyrosine hydroxylase (TH) to label dopamine varicosities and by pre-embedding immunogold for CalR. Electron microscopic examination of layers 1-3 revealed numerous TH-immunoreactive (TH-ir) terminals, but few were located in the vicinity of CalR-ir dendrites. Although close appositions were sometimes detected between these labeled processes, no synaptic inputs from TH-ir terminals to CalR-ir dendrites were observed. However, in adjacent sections from the same animals, TH-ir terminals were observed to synapse on GABA-ir dendrites. These findings suggest that dopamine afferents to the monkey PFC target the subclasses of GABA interneurons that do not contain CalR.

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Citations

Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Herbert Y MeltzerJunji Ichikawa
Jan 16, 2003·Physiology & Behavior·G González-BurgosG Barrionuevo
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Dec 17, 2011·Annals of the New York Academy of Sciences·Marisela Morales, Virginia M Pickel
Nov 4, 2009·Journal of Neuroscience Research·Natalia Omelchenko, Susan R Sesack
Jan 21, 2004·Biological Psychiatry·Yukiori Goto, Patricio O'Donnell
Jul 31, 2003·The European Journal of Neuroscience·Barbara K LipskaDaniel R Weinberger
Jun 27, 2007·Journal of Anatomy·Ruth Benavides-Piccione, Javier DeFelipe
Apr 21, 2016·Neuroscience and Biobehavioral Reviews·Liana Fattore, Marco Diana
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Aug 10, 2001·Journal of Neurophysiology·A T Gulledge, D B Jaffe
Oct 17, 2017·Trends in Neurosciences·Daniel Hoops, Cecilia Flores

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