Ultrastructural background of albuminuria in rats with passive Heymann nephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
T AraiA Hishida

Abstract

Although it is widely known that proteinuria in rats with passive Heymann nephritis (PHN) is prevented by treatment with cobra venom factor (CVF), the precise mechanisms of complement-dependent proteinuria have not been fully elucidated. The aim of this study was to evaluate morphologically whether the size of subepithelial electron-dense deposits (EDDs) contributes to the onset of albuminuria. The size of subepithelial EDDs and anionic sites in the lamina rarae externa (LRE) overlaid with subepithelial EDDs were evaluated by ruthenium red and compared between PHN and PHN treated with CVF in rats. Overt albuminuria was present on days 3 and 4 after injection of anti-Fx1A. CVF-treatment of rats with PHN prevented albuminuria (PHN + CVF: n = 6) (53.6 +/- 38.8 vs 1.02 +/- 0.55 mg/day, P < 0.01, on day 4). Rat C3 was detected along the glomerular capillary walls on day 4 post-injection in rats with PHN, but not in rats with PHN + CVF. Subepithelial EDDs were observed in both groups. Quantitative morphometric analysis revealed that CVF-treatment decreased the size of subepithelial EDDs as well as the extent of retraction of glomerular epithelial cells. In both groups the density of anionic sites in the LRE overlaid with EDDs was dec...Continue Reading

Citations

Oct 26, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shin-ichi TakedaEiji Kusano
Jun 1, 2013·Journal of Toxicologic Pathology·Akihito ShimoiMitsutoshi Watanabe
Nov 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neil S SheerinSteven H Sacks
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Timothy SpicerBruce M Hall
Sep 26, 2002·Clinical and Experimental Immunology·N S Sheerin, S H Sacks

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