PMID: 11897843Mar 19, 2002Paper

Ultrastructural basis of synaptic transmission between endbulbs of Held and bushy cells in the rat cochlear nucleus

The Journal of Physiology
Madeleine J Nicol, B Walmsley

Abstract

Auditory nerve fibres make large excitatory synaptic contacts, the endbulbs of Held, with bushy cells in the anteroventral cochlear nucleus (AVCN). We have used serial-section electron microscopy to reconstruct seven endbulbs of Held in contact with three different AVCN bushy cells from a 25-day-old rat, as a basis for interpreting our previous physiological results at this connection. Four endbulbs of Held contacting the same bushy cell were completely reconstructed. The number of separate synaptic specializations within these endbulbs varied from 85 to 217, with a mean of 155. Detailed measurements were obtained from high magnification segments of four endbulbs contacting three different bushy cells. Large variability was found in the size of synaptic specializations within an individual endbulb. The size of postsynaptic densities (PSDs) varied between endbulbs (mean PSD area 0.03, 0.07, 0.07 and 0.18 microm(2); n = 4 endbulbs). The number of morphologically docked vesicles at individual specializations within the same endbulb varied considerably (between 1 and 102). The mean number of morphologically docked vesicles per specialization differed between endbulbs (mean numbers of docked vesicles per specialization = 2.1, 3.7, 5...Continue Reading

References

Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Nov 1, 1982·The Anatomical Record·G R NeisesR L Gulley
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·C F Stevens, T Tsujimoto
Jan 29, 1996·The Journal of Comparative Neurology·D K RyugoT Pongstaporn
Aug 25, 1997·The Journal of Comparative Neurology·D K RyugoJ K Niparko
Mar 14, 1998·Trends in Neurosciences·B WalmsleyR E Fyffe
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·T Schikorski, C F Stevens
Apr 15, 2000·The Journal of Physiology·S OleskevichB Walmsley
Nov 5, 2005·Journal of Cellular Physiology·Bramanandam Manavathi, Rakesh Kumar

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Citations

Aug 10, 2006·Cell and Tissue Research·Ralf Schneggenburger, Ian D Forsythe
Aug 26, 2006·Cell and Tissue Research·Astrid Rollenhagen, Joachim H R Lübke
Jul 26, 2002·Current Opinion in Neurobiology·Laurence O Trussell
Jul 10, 2009·Journal of Neurophysiology·Hua Yang, Matthew A Xu-Friedman
Aug 13, 2010·Journal of Neurophysiology·Soham Chanda, Matthew A Xu-Friedman
Jan 29, 2010·Journal of Neurophysiology·Soham Chanda, Matthew A Xu-Friedman
Mar 28, 2008·Journal of Neurophysiology·Hua Yang, Matthew A Xu-Friedman
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hua Yang, Matthew A Xu-Friedman
Apr 23, 2005·The Journal of Physiology·Brian BillupsIan D Forsythe
Aug 28, 2004·The Journal of Physiology·S OleskevichB Walmsley
Feb 14, 2006·The Journal of Physiology·Bruce WalmsleyRobert E W Fyffe
Feb 12, 2011·Hearing Research·Jahn N O'NeilDavid K Ryugo
Apr 8, 2010·Trends in Neurosciences·J Gerard G Borst
Apr 22, 2008·Neuroscience·P X Joris, P H Smith
Oct 7, 2015·Progress in Neurobiology·Clarke R Slater
Jun 21, 2012·Journal of Neuroscience Research·Tetsuji SekiyaBarbara Canlon
Jan 21, 2014·The EMBO Journal·Alejandro Mendoza SchulzTobias Moser
Oct 13, 2004·Journal of Physiology, Paris·Catherine E Carr, Christine Köppl
Feb 11, 2014·Hearing Research·Wei-Ming Yu, Lisa V Goodrich
Apr 22, 2015·Cell and Tissue Research·Eckhard FriaufMartin F Fuhr
Dec 24, 2002·Neuron·Holger TaschenbergerHenrique von Gersdorff
Jan 8, 2015·Frontiers in Neural Circuits·Jana NerlichIvan Milenkovic
Jul 31, 2016·Hearing Research·Catherine J ConnellyMichael A Muniak
Apr 12, 2005·Neuron·Abigail L Person, David J Perkel
Mar 30, 2004·The Journal of Comparative Neurology·Catherine E Carr
Nov 10, 2017·Frontiers in Synaptic Neuroscience·Tanvi ButolaTobias Moser
Jul 3, 2002·Nature Reviews. Neuroscience·Harold L Atwood, Shanker Karunanithi
Sep 15, 2005·Journal of Neurophysiology·Matthew A Xu-Friedman, Wade G Regehr
Apr 10, 2015·Journal of Neurophysiology·Yang Yang, Matthew A Xu-Friedman
Apr 5, 2017·Frontiers in Computational Neuroscience·Marek Rudnicki, Werner Hemmert

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