Ultrastructural changes in cirrhotic and noncirrhotic patients due to hepatectomy

Journal of Hepato-biliary-pancreatic Surgery
Chumpon WilasrusmeeDilip S Kittur

Abstract

Alterations at the ultrastructural level can be identified prior to histological change in the early phase of irreversible cell damage. The aim of this investigation was to compare the ultrastructural changes in cirrhotic and noncirrhotic liver in response to ischemic and reperfusion injury due to hepatectomy. Hepatic resections using the same technique were performed in cirrhotic and noncirrhotic patients. Three biopsy specimens (Tru cut) from each patient, in the unresected part of the liver, were studied by transmission electron microscopy: immediately after laparotomy, before releasing of the porta hepatis clamp (ischemic phase), and 30-45 min after reperfusion. All patients did well after surgery, except for 1 cirrhotic patient who died of liver failure. There were no significant differences in operative time, blood loss, and inflow occlusion times in any of the 15 patients. We found that morphological changes were the same in the 10 non-cirrhotic and 4 cirrhotic patients. Changes during the ischemic phase included nuclear membrane deformity, focal chromatin condensation at the nuclear margin, and swelling of both mitochondria and endoplasmic reticulum. In the reperfusion phase, there were early irreversible changes in the...Continue Reading

Citations

May 25, 2012·Acta Oto-laryngologica·Min-Hyun ParkSeung-Ha Oh
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
Mar 27, 2007·Journal of Hepato-biliary-pancreatic Surgery·Anna GillispieGreg Nowak
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
Jun 4, 2010·Arquivos De Gastroenterologia·Bruno CogliatiFrancisco Javier Hernandez-Blazquez

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