PMID: 7336438Jan 1, 1981Paper

Ultrastructural changes in isolated rat hepatocytes after incubation with carbon tetrachloride

Toxicology
N H Stacey, J C Fanning

Abstract

Suspensions of rat hepatocytes, isolated by a collagenase-based perfusion technique, were incubated with carbon tetrachloride (CCl4) for up to 60 min. Control incubated cells examined by transmission electron microscopy had an essentially normal substructure. Treatment with CCl4, however, resulted in a loss of microvilli at the cell membrane, disorganization of the RER, the appearance of condensed membranes, vacuoles within mitochondria and cellular protrusions. While some of the alterations are similar to those observed after in vivo CCl4 exposure, others are not. This suggests that the mechanism of in vitro damage may not be identical to that in vivo. Further investigation of the differences, such as the cellular protrusions, may yield increased understanding of the toxicity induced by CCl4 in the whole animal.

References

Jul 1, 1978·Toxicology and Applied Pharmacology·N Stacey, B G Priestly
Feb 1, 1978·Experimental and Molecular Pathology·T D LindstromH Remmer
Nov 1, 1978·Toxicology and Applied Pharmacology·D K AlbrechtH Remmer
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·M FrimmerJ Porstendörfer
Nov 1, 1973·CRC Critical Reviews in Toxicology·R O Rechnagel, E A Glende
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D PerrissoudM F Maignan
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE

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Citations

Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M F MarianiG D van Rossum
Dec 30, 1998·Pharmacology & Toxicology·D E Johnston, C Kroening
Oct 1, 1983·Experimental and Molecular Pathology·R M WalkerW J Racz
Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·S CaiazzaM Ferrari
Dec 1, 1987·Toxicology and Industrial Health·C A Tyson
Jan 1, 1989·Toxicology and Industrial Health·C A Tyson, N H Stacey
Apr 3, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Srinivasa Subramaniam
Dec 1, 1985·Experimental and Molecular Pathology·D WangH Sidransky
Jan 1, 1990·Toxicology and Applied Pharmacology·V KukongviriyapanN H Stacey

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