Ultrastructural changes of the gemifloxacin on Achilles tendon in immature rats: comparison with those of ciproxacin and ofloxacin

Basic & Clinical Pharmacology & Toxicology
Chun-Sik BaeSung-Chul Lim

Abstract

Gemifloxacin is a synthetic fluoroquinolone antimicrobial agent that exhibits potent activity against most Gram-negative and Gram-positive organisms, and has a comparatively low chondrotoxic potential in immature animals. This study examined the effects of gemifloxacin on the Achilles tendons in immature Sprague-Dawley rats treated by oral intubation once daily for 5 consecutive days from postnatal week 4 onward at doses of 0 (vehicle), and 600 mg/kg body weight. Ofloxacin or ciprofloxacin were used for comparison. The Achilles tendon specimens were examined by electron microscopy. In comparison with the vehicle-treated controls, there were ultrastructural changes in all samples from the gemifloxacin-, ofloxacin-, and ciprofloxacin-treated rats. Degenerative changes were observed in the tenocytes, and the cells that detached from the extracellular matrix were recognizable. The degree of degenerative changes and the number of degenerated cells in the Achilles tendon were significantly higher in the treated group than in the control group. Moreover, among the quinolone-treated groups, these findings were most significant in the ofloxacin-treated group, and least significant in the gemifloxacin-treated group. It is unclear what th...Continue Reading

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Citations

Mar 29, 2012·The Tohoku Journal of Experimental Medicine·Ferda Kaleagasioglu, Ercan Olcay
Dec 3, 2015·Regulatory Toxicology and Pharmacology : RTP·Thomas BourgeoisBoris Matrot
Jul 27, 2011·Environmental Toxicology and Pharmacology·Bikash RoyTapan Kumar Pal
Jun 29, 2010·Regulatory Toxicology and Pharmacology : RTP·Bikash RoyTapan Kumar Pal
Mar 9, 2017·Calcified Tissue International·Lia MillucciAnnalisa Santucci

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