Ultrastructural changes of the myocardium in the embryonic rat heart

The Anatomical Record
M W KnaapenA C Wenink

Abstract

Ultrastructural changes of the embryonic heart have been described, and quantitative studies have reported the changes of cellular organelles in late fetal and postnatal development. However, no specific data are available on the quantitative morphology of the individual segments and intersegmental junctions of the early embryonic heart, although these components must have different functions. We measured the absolute volumes of glycogen, Golgi complex, myofibrils, mitochondria, and the surface areas of the rough endoplasmic reticulum and mitochondrial cristae in the different regions of the embryonic rat heart by using stereological tools. During embryonic development, the cardiac segments and intersegmental junctions increase their glycogen volume. The sinoatrial junction and primary fold show a more rapid increase than all the other cardiac regions, whereas the atrioventricular canal shows a high level of glycogen content throughout the period studied. The Golgi complex and rough endoplasmic reticulum show a conspicuous decrease from day 15 onward. The cellular content of myofibrils and mitochondria and the surface area of the mitochondrial cristae show a gradual increase from day 11 to day 17 of development, but full matura...Continue Reading

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Citations

Nov 23, 2006·BMC Developmental Biology·Mira D LozykMichal Opas
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Haijun GongRussell Schwartz
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David SedmeraEric Raddatz
Aug 9, 2001·Coronary Artery Disease·G D DispersynM Borgers
Jul 5, 2006·The Journal of Cell Biology·Yusong Guo, Adam D Linstedt
Jul 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoyoshi AoyamaRobert E Poelmann
Sep 18, 2007·Anatomical Science International·Sachiko MatsuuraAkio Kikuta
Dec 12, 2001·Journal of Molecular and Cellular Cardiology·J AusmaM Borgers
May 9, 2002·Biochimica Et Biophysica Acta·Geoffrey P Dobson, Uwe Himmelreich

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