Ultrastructural changes of the subendocardium in ischemic and cardioplegic states before and after reperfusion

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
B TörökK Trombitás

Abstract

Unprotected and preserved myocardial ultrastructures were analyzed in prepump and postreperfused states. The experiments were divided into three groups: group 1 - normal hearts functioning 60 min in a special heart-lung model; group 2 - hearts with 30, 60, 90 and 120 min of normothermic ischemia plus 60 min of recirculation; group 3 - hearts with 30, 60, 90 and 120 min of hypothermic cardioplegia plus 60 min of recirculation. Anoxic hearts could be set in motion, but after longer anoxia the symptoms of stone-heart regularly appeared. Reperfusion induced grave ultrastructural changes both in the energy system (mitochondrial edema, rupture and lysis of cristae) and myofibrils (hypercontraction, elongation, Z line anomalies). Cardioplegic hearts showed a dynamic recovery. However, after reperfusion, characteristic sporadic signs of ischemia could always be demonstrated.

Citations

Nov 1, 1983·Basic Research in Cardiology·B TörökT Simor
May 1, 1985·Clinical Reviews in Allergy·W F WilloughbyG F Gerberick

Related Concepts

Metazoa
Coronary Heart Disease
Canis familiaris
Heart
Heart Arrest, Induced
Myocardium
Organ Preservation
Perfusion

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