PMID: 6111887Jan 1, 1981Paper

Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice

Acta Neuropathologica
A W VorbrodtL Iwanowski

Abstract

Alkaline phosphatase, 5'-nucleotidase nucleoside diphosphatase and thiamine pyrophosphatase activities were studied by cytochemical method applied to electron microscopy of brain microvasculature in normal and scrapie infected mice. In control mice, the major location of all phosphatases studied was the luminal plasma membrane of the endothelial cells. In scrapie infected mice, changes in activity and distribution of the above mentioned phosphatases manifested themselves in the appearance of the reaction product on the abluminal side of the vessel wall. Our data presents evidence that following scrapie infection, these enzymes change their specific localization along the endothelial cell membranes. These enzymatic changes may serve as useful indicators of some alterations in the mammalian blood-brain barrier following infection by scrapie agent in the mouse.

References

Feb 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R J Uusitalo, M J Karnovsky
Dec 23, 1977·Brain Research·B M Djuricić, B B Mrsulja
Jan 1, 1976·Advances in Experimental Medicine and Biology·H McIlwain
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A B Novikoff
Jul 1, 1979·The American Journal of Cardiology·A M Rissanen
Dec 15, 1978·Brain Research·G W KreutzbergP Schubert
Jan 1, 1977·Journal of Neurochemistry·W M Pardridge, W H Oldendorf
Dec 12, 1975·Science·H M WiśniewskiH Fraser
Feb 1, 1976·The Journal of Physiology·H Davson
Jun 1, 1972·Archives of Neurology·A HiranoA J Gomori
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Mar 1, 1969·The Journal of Cell Biology·M W Brightman, T S Reese
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Aug 1, 1980·Journal of Neurochemistry·S K WilliamsM W Bitensky
Feb 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J J BermanG M Williams
Aug 1, 1980·Journal of Neurochemistry·W CammerW T Norton
Jun 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·A B NOVIKOFF, S GOLDFISCHER
Jan 1, 1964·Journal of Neuropathology and Experimental Neurology·R M TORACK, R J BARRNETT
Feb 1, 1964·Journal of Ultrastructure Research·V T MARCHESI, R J BARRNETT

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Citations

Jan 1, 1989·Acta Neuropathologica·K KawaiF Ikuta
Jan 1, 1991·Journal of the Neurological Sciences·T W PolderM Wijers-Rouw
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Eain M Cornford, Shigeyo Hyman
Jan 1, 1988·Progress in Histochemistry and Cytochemistry·A W Vorbrodt
Sep 1, 1984·Microvascular Research·M E MichelS I Rapoport
Jan 1, 1982·Annals of the New York Academy of Sciences·H M Wisniewski, P B Kozlowski
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas Worzfeld, Markus Schwaninger
Jul 1, 1984·Pathology·C L Masters
Nov 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G A LevyA M Rappaport
Jan 1, 1981·Acta Neuropathologica·A W VorbrodtA S Lossinsky

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