Abstract
The ultrastructure of Langerhans cells has not been fully investigated in diabetes-associated gingival tissues. The present study was carried out to investigate the ultrastructure of gingival Langerhans cells in alloxan-induced diabetic rats. Gingival biopsies were obtained from 22 diabetic and 18 control rats. Langerhans cells were observed by transmission electron microscopy (TEM) in the basal layers of healthy oral epithelium. On rare occasions, Langerhans cells were found in the suprabasal layers of the oral epithelium. Langerhans cells in the oral epithelium of diabetic rats were seen in the basal and suprabasal layers. Usually, Langerhans cells had clear cytoplasm and convoluted or indented nuclei and few or no specific granules. The clear cytoplasm contained mitochondria, lysosomes and a small number of rough-surfaced endoplasmic reticulum regions, but it lacked tonofilament. Occasionally, centrioles were also observed in the cytoplasm. The membrane of Langerhans cells had no junctional complexes such as desmosomes. In diabetic rats, Langerhans cell precursors were developed into specific granule-bearing cells. Both Langerhans cells and their granules were more frequent in the gingiva of diabetic rats than in the control...Continue Reading
References
Dec 1, 1978·Journal of Ultrastructure Research·E M Rodríguez, I Caorsi
Oct 1, 1990·The Journal of the American Dental Association·M ShlossmanR J Genco
Oct 1, 1985·The American Journal of Anatomy·W G YoungA R Hosking
Mar 1, 1989·Journal of Periodontal Research·V BaelumE Dabelsteen
Dec 1, 1989·Diabetes·H A VoorbijH A Drexhage
Nov 1, 1986·Journal of Periodontal Research·G M Newcomb, R N Powell
May 1, 1985·Journal of Periodontal Research·S TakehanaM Mizohata
Aug 1, 1988·Diabetologia·A G Ziegler, E Standl
Jan 1, 1986·Archives of Oral Biology·G M Newcomb, R N Powell
Jan 1, 1985·Journal of Periodontology·C F DiFrancoE Connelly
Apr 1, 1971·The Journal of Investigative Dermatology·L H HutchensM A Clarke
Mar 1, 1967·Archives of Oral Biology·J P Waterhouse, C A Squier
Jan 1, 1966·Journal of Periodontal Research·H E Schroeder, J Theilade
May 1, 1973·Journal of Ultrastructure Research·R T Gemmell
Oct 1, 1968·American Journal of Obstetrics and Gynecology·M S YounesS A Bencosme
Jan 1, 1980·Immunological Reviews·G StinglS I Katz
May 1, 1984·The Histochemical Journal·J A ThomasD F Easton
Nov 1, 1983·The Journal of the American Dental Association·M Manouchehr-Pour, N F Bissada
Jul 1, 1982·Journal of Clinical Periodontology·G M NewcombR N Powell
May 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T LombardiE Budtz-Jörgensen
Jan 1, 1996·Journal of Periodontology·M GünhanH Bostanci
Feb 9, 2002·Oral Diseases·T SuzukiK Motegi
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun RatzingerNikolaus Romani