Ultrastructural distribution of endogenous IgGs in the glomerular wall of control and diabetic rats.

The Histochemical Journal
M Desjardins, M Bendayan

Abstract

Endogenous IgG molecules were revealed with high resolution EM over the glomerular wall in renal tissues sampled from short and longterm control and streptozotocin induced diabetic rats by applying the protein A-gold immunocytochemical approach. In tissues from control animals, IgG antigenic sites were revealed on the subendothelial side of the basement membrane, the epithelial side being only weakly labelled. In contrast, in longterm diabetic animals IgG antigenic sites were present throughout the entire thickness of the basement membrane, and in patches closely associated with the plasma membrane of the epithelial cells. Deposits of basement membrane-like material present in the mesangial area were also highly labelled for IgG. Numerous intensely labelled lysosome-like structures were present in the epithelial cells. Morphometrical evaluation of the distribution of the labelling over the basement membrane confirmed these observations. In control animals a peak of labelling was found at 30 nm from the endothelial cell region corresponding to the subendothelial side of the lamina densa. In longterm diabetic animals the labelling was more uniformly distributed throughout the entire thickness of the basement membrane. These data ...Continue Reading

References

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Citations

Nov 5, 1997·Hearing Research·G N ThomopoulosB A Schulte
May 1, 1991·The Journal of Cell Biology·M Desjardins, M Bendayan
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Lachapelle, M Bendayan
Jan 1, 1995·Progress in Histochemistry and Cytochemistry·M Bendayan
Sep 1, 1992·Microscopy Research and Technique·L Ghitescu, M Bendayan
Jul 15, 2005·American Journal of Physiology. Renal Physiology·I Londono, M Bendayan
Jul 12, 2002·Microscopy Research and Technique·Moise Bendayan

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