Ultrastructural diversity of inclusions and aggregations in the lumbar spinal cord of SOD1-G93A transgenic mice

Brain Research
Yansu GuoZhongyao Li

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of lumbar spinal cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently according to the specified locations. This study provided further information to the previous reports about pathological changes of ALS.

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Citations

Jun 28, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Peter I JoyceAbraham Acevedo-Arozena
Mar 7, 2012·The European Journal of Neuroscience·T PrellJ Grosskreutz
Apr 2, 2016·Brain Research·Céline Ruegsegger, Smita Saxena
Apr 12, 2016·Brain Research·Sonam Parakh, Julie D Atkin
Mar 15, 2015·Experimental & Molecular Medicine·Aaron Ciechanover, Yong Tae Kwon
May 14, 2015·F1000Research·Bhavin Parekh
Jun 28, 2018·Molecular Neurobiology·Wu ChenXin Wang
May 14, 2020·Protein Engineering, Design & Selection : PEDS·Filip ClaesJoost Schymkowitz
Jun 20, 2020·Current Topics in Medicinal Chemistry·Md Tanvir KabirMohamed M Abdel-Daim
Apr 25, 2019·ACS Chemical Neuroscience·Vignesh KotianPallab Bhattacharya
Aug 12, 2017·Neurochemistry International·Carlo RodolfoFrancesco Cecconi

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