PMID: 11315948Apr 24, 2001Paper

Ultrastructural dynamics of human testicular cords from 6 to 16 weeks of embryonic development. Study by transmission and high resolution scanning electron microscopy

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
R HeynP M Motta

Abstract

When the embryo is 6-week-old the gonad is composed mostly of migrating primordial germ cells, surface coelomic mesothelium and mesenchymal cells. At 7 weeks of gestation (wg) testicular cords consist of prespermatogonia, larger, with a more regular outline and higher mitotic activity than primordial germ cells, embraced by somatic pre-Sertoli cells. The morphofunctional development of Sertoli cells defines testicular differentiation. Towards 7.5 wg the gonad is finally in its differentiated stage; the basal lamina of the cords becomes distinguishable, testicular cords radially branch and elongate, and Leydig cells are clearly recognized. Primordial germ cells are large and spherical, with rounded and eosinophilic nuclei and large nucleoli. Pre-Sertoli cells, in turn, show round or columnar nuclei and rough endopasmic reticulum. Prespermatogonia and mostly pre-Sertoli cells actively proliferate. Many interdigitations and cytoplasmic processes are observed between neighboring pre-Sertoli cells and between pre-Sertoli cells and prespermatogonia. A sort of com partmentalization is established inside the cords in which pre-Sertoli cells tend to localize closer to the basal membrane embracing the prespermatogonia with long and thin ...Continue Reading

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