PMID: 9172835Jan 1, 1997Paper

Ultrastructural effects of lactoferrin binding on Giardia lamblia trophozoites

The Journal of Eukaryotic Microbiology
J M TurchanyF D Gillin

Abstract

Lactoferrin and its derived N-terminal peptide may be important host defenses against Giardia lamblia. We showed earlier that lactoferrin and the derived peptides have potent giardicidal activity in vitro. Using indirect immunofluorescence, we now demonstrate binding of lactoferrin and the peptides to the live trophozoite surface. Iron strongly inhibited binding of lactoferrin, and decreased binding of the peptides, while certain divalent metal ions decreased binding of all forms by about half. Lactoferrin and the peptides caused striking and complex morphologic changes in the trophozoite plasmalemma, endomembranes and cytoskeleton, and increased the electron density of the lysosome-like peripheral vacuoles.

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Citations

May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theresa J OchoaThomas G Cleary
Jun 6, 2014·Tropical Medicine & International Health : TM & IH·Ina DanquahFrank P Mockenhaupt
Jan 13, 2015·Biochimica Et Biophysica Acta·Constanza FelizianiMaria C Touz
Feb 7, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hugo Aguilar-DiazNidia Leon-Sicairos
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Jose Luis ParedesAlejandro Castellanos-González
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nidia León-SicairosMireya de la Garza
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Zarzosa-MorenoMireya de la Garza

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