PMID: 9165715Apr 1, 1997Paper

Ultrastructural evidence for association of vascular dendritic cells with T-lymphocytes and with B-cells in human atherosclerosis

Journal of Submicroscopic Cytology and Pathology
Y V Bobryshev, T Watanabe

Abstract

It has been previously demonstrated that dendritic cells are involved in human atherogenesis and immunohistochemical analysis indicated that S100+/CD1a+ vascular dendritic cells co-localize with lymphocytes in atherosclerotic lesions. Despite the high frequency of co-localization of vascular dendritic cells and lymphocytes in cell-rich areas, different type intimal cells were often intermingled and very closely apposed, which precluded determining whether vascular dendritic cells and lymphocytes specifically contacted each other or were simply densely packed together. Therefore, we undertook the present electronmicroscopical examination to see if vascular dendritic cells form direct contacts with lymphocytes in human atherosclerotic lesions. Serial sectioning of lymphocyte-rich areas of the human atherosclerotic aortas showed that vascular dendritic cells exhibiting a well developed tubulovesicular apparatus were located amongst T-lymphocytes and that through their processes, vascular dendritic cells formed multiple contacts with T-lymphocytes. In these contacts, vascular dendritic cell processes exhibited hypertrophied cisterns of the tubulovesicular system, which suggests the activation of vascular dendritic cells. From our o...Continue Reading

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