Abstract
The phenomenon of unstable expression of gap junction's proteins connexins remains a "visiting card" of astrocytic tumors with various degrees of malignancy. At the same time, it stays unclear what is detected by the positive expression of connexins in astrocytic tumors: gap junctions, hemi-channels, or connexin proteins in cytosol. In the present work, for the first time, we demonstrate an ultrastructural evidence of gap junctions in pleomorphic xanthoastrocytoma, a rare primary brain tumor, the intercellular characteristics of which are poorly studied and remain very discursive and controversial. The primary tumor mass was resected during craniotomy from a 57-old patient diagnosed with pleomorphic xanthoastrocytoma Grade II based on the histopathological analysis. The immunohistochemical study was conducted with primary antibodies: Neurofilament, Myelin basic protein, Glial fibrillary acidic protein, and Synaptophysin. For electron microscopic examination fragments of tumor tissue were fixed in a glutaraldehyde, postfixed in a 1% OsO4, dehydrated and embedded into resin. After the detailed clinical, histological, and immunohistochemical study we revealed some ultrastructural characteristics of the tumor, as well as the first ...Continue Reading
References
Nov 1, 1979·Cancer·J J KepesL F Eng
Aug 1, 1992·Neurosurgery·C F LindboeJ J Kepes
Jul 1, 1992·Journal of Neurosurgery·A FurutaR Tanaka
Jan 1, 1995·Acta Neuropathologica·R KordekP P Liberski
Jan 1, 1996·The American Journal of Surgical Pathology·S Z PowellT A Eskin
Jan 1, 1997·Pathology, Research and Practice·I VajtaiA Aguzzi
Apr 7, 2000·Brain Research. Brain Research Reviews·J I Nagy, J E Rash
Jul 14, 2001·Journal of Neuro-oncology·A Korshunov, A Golanov
Jul 24, 2001·Neuro-oncology·M FouladiA Gajjar
Jan 11, 2002·Ultrastructural Pathology·T HiroseB W Scheithauer
Mar 27, 2002·The American Journal of Surgical Pathology·Caterina GianniniScott R VandenBerg
Apr 26, 2003·Arquivos de neuro-psiquiatria·Oswaldo Ignácio de TellaPaulo Henrique Aguiar
Aug 30, 2003·Archives of Pathology & Laboratory Medicine·Hilda Martinez-DiazAnthony T Yachnis
Jun 1, 2010·Journal of Cellular Biochemistry·Sophie CrespinWun-Chey Sin
Jan 29, 2011·Acta Neuropathologica·Genevieve SchindlerAndreas von Deimling
Apr 12, 2011·PloS One·Dora Dias-SantagataSandro Santagata
Jun 15, 2011·Neuroscience and Biobehavioral Reviews·Ekrem Dere, Armin Zlomuzica
Nov 9, 2011·Biochimica Et Biophysica Acta·Wun-Chey SinMarc Mesnil
Dec 6, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tamara M VuKatharine J Drummond
May 23, 2012·Biochimica Et Biophysica Acta·Linda Matsuuchi, Christian C Naus
Apr 30, 2013·Handbook of Clinical Neurology·Ahsan N V Moosa, Elaine Wyllie
Nov 21, 2013·Acta Neuropathologica Communications·Cristiane M IdaCaterina Giannini
Jan 25, 2014·Cell Death & Disease·E GangosoA Tabernero
Aug 12, 2014·Bulletin of Experimental Biology and Medicine·G M YusubalievaV P Chekhonin
Oct 17, 2014·Brain Pathology·Cristiane M IdaCaterina Giannini
Feb 26, 2015·Neuroscience·A TaberneroJ M Medina
Jul 15, 2015·Oncogene·W C SinC C Naus
Nov 5, 2015·Nature·Matthias OsswaldFrank Winkler
May 10, 2016·Acta Neuropathologica·David N LouisDavid W Ellison
Jun 3, 2016·PloS One·Laura-Nanna LohkampArend Koch
Dec 17, 2016·Neuroscience·Takaichi Fukuda
Mar 16, 2017·Arkhiv patologii·E Yu KirichenkoA K Logvinov
Nov 7, 2017·Neuro-oncology·Jun WangShi-Cang Yu
Apr 12, 2018·International Journal of Molecular Sciences·Miaki UzuHiromi Sato
Jan 10, 2019·Frontiers in Oncology·Maksim SinyukJustin Lathia
Mar 3, 2019·Cancers·Anja BeckmannCarola Meier