PMID: 10862504Jun 22, 2000

Ultrastructural evidence of the protective effect of Na+/H+ exchange inhibition on the in vitro damage induced by ischaemia reperfusion in the interventricular septum of the rabbit heart

Pharmacology & Toxicology
P SalinasS Barrigon


We investigated the effects of the Na+/H+ antiporter inhibitor, dimethylamiloride, on myocardial injury after 1 h global ischaemia and 30 min. reperfusion in the isolated arterially perfused interventricular septum of the rabbit heart. After ischaemia and reperfusion challenge, dimethylamiloride significantly increased the recovery of developed tension in a dose-dependent manner, and significantly decreased the maximal increase in resting tension. Ultrastructural analysis of myocytes submitted to the experimental in vitro model supported functional maintenance of physiologically-like conditions. Where myocardial portions were submitted to ischaemic conditions and reperfusion, myocyte cell damage reached usual characteristics of infarct-like induced lesions. Intracellular oedema, severe disruption of myofibrils with loss of muscle striation and both swelling and fragmentation of mitochondria were the main characteristics observed. Dimethylamiloride treatment clearly modifies ultrastructural findings towards the normalization of cell shape and structure, only a slight-middle intracellular oedema and contraction bands were found. On the basis of the present results, we suggest that the protective effects exhibited by dimethylamilo...Continue Reading


Oct 19, 2007·Clinical and Experimental Pharmacology & Physiology·María G Marina PrendesAlicia Varela
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May 21, 2016·Heart·Sascha KahlfußKadir Yilmaz

Related Concepts

Myocardial Contraction
Mycobacterium Avium-intracellulare Infection
Abnormal Fragmented Structure
SLC9A1 gene
Cell Injury
Tang Hsi Ryu Syndrome
Muscle Cells
Sodium-Hydrogen Antiporter

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