Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation.

The Journal of Comparative Neurology
Elizabeth M WatersTeresa A Milner

Abstract

Progesterone's effects on hippocampus-dependent behavior and synaptic connectivity maybe mediated through the progestin receptor (PR). Although estrogen induces PR mRNA and cytosolic PR in the hippocampus, nuclear PR immunoreactivity is undetectable by light microscopy, suggesting that PR is present at extranuclear sites. To determine whether this is the case, we used immunoelectron microscopy to examine PR distribution in the hippocampal formation of proestrus rats. Ultrastructural analysis revealed that PR labeling is present in extranuclear profiles throughout the CA1 and CA3 regions and dentate gyrus, and, in contrast to light microscopic findings, in nuclei of a few pyramidal and subgranular zone cells. Most neuronal PR labeling is extranuclear and is divided between pre- and postsynaptic compartments; approximately 30% of labeled profiles were axon terminals and 30% were dendrites and dendritic spines. In most laminae, except in CA3 stratum lucidum, about 15% of PR-immunoreactive profiles were unmyelinated axons. In stratum lucidum, where the mossy fiber axons course, more than 50% of PR-labeled profiles were axonal. The remaining 25% of PR-labeled profiles were glia, some resembling astrocytes. PR labeling is strongly de...Continue Reading

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·I Jung-TestasE E Baulieu
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Feb 26, 1999·Journal of Neurophysiology·M R FoyT W Berger
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A TibbettsB W O'Malley
Dec 16, 2000·The Journal of Comparative Neurology·T A MilnerS E Alves
Aug 25, 2001·Annual Review of Neuroscience·R Yuste, T Bonhoeffer
May 9, 2002·Neuroreport·Jon Nilsen, Roberta Diaz Brinton
Oct 16, 2002·Brain Research Bulletin·Christian Guerra-AraizaIgnacio Camacho-Arroyo
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·A M GhoumariE-E Baulieu
Jan 1, 2004·Progress in Brain Research·Pablo Villoslada, Claude P Genain
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shao-Hua YangJames W Simpkins
Jun 3, 2004·The Journal of Comparative Neurology·Michelle M AdamsJohn H Morrison
Feb 12, 2005·Molecular Endocrinology·Ellis R Levin
Aug 9, 2005·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Madeline E Rhodes
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Lori L McMahon
Aug 30, 2005·The Journal of Comparative Neurology·Teresa A MilnerStephen E Alves
Apr 1, 2006·Neuron Glia Biology·Jai-Yoon SulPhilip G Haydon
Apr 25, 2006·Journal of Molecular Neuroscience : MN·Alejandro F De NicolaMichael Schumacher
Jun 24, 2006·Brain Research·Emily R RosarioChristian J Pike
Aug 15, 2006·Glia·Luis M Garcia-Segura, Roberto C Melcangi
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Lori L McMahon
Aug 22, 2006·Annual Review of Pharmacology and Toxicology·Catherine S Woolley

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Citations

Feb 1, 2012·Behavioral Neuroscience·Bruce S McEwenElizabeth M Waters
Apr 28, 2012·Neuroendocrinology·Shaila K Mani, Jeffrey D Blaustein
Sep 17, 2014·Climacteric : the Journal of the International Menopause Society·B S McEwen
Nov 17, 2009·Biochimica Et Biophysica Acta·Karyn M FrickLauren L Harburger
Mar 26, 2009·Frontiers in Neuroendocrinology·Alejandro F De NicolaMichael Schumacher
Jun 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G M Gargiulo-MonachelliM J Strong
Jun 19, 2015·Experimental Physiology·Federica GhersaMarilina Casais
Jan 10, 2012·Biological Psychiatry·Saloua BenmansourAlan Frazer
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·M C Gonzalez DeniselleAlejandro F De Nicola
Aug 19, 2014·Behavioural Brain Research·Jennifer J TuscherKaryn M Frick
Jun 11, 2016·Progress in Neurobiology·Estefanía Acaz-FonsecaGeorge E Barreto
Jun 5, 2016·Journal of Neuroendocrinology·L Zubeldia-BrennerH E Lara
Aug 22, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lisa WesselCarsten Theiss
Apr 20, 2016·Reproductive Sciences·Annelyn Torres-ReverónCaroline B Appleyard
Jun 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G P IvanovaL M Vasilenko
Sep 25, 2010·Annals of the New York Academy of Sciences·Bruce S McEwen
Jun 26, 2015·Physiological Reviews·Yuko HaraJohn H Morrison
Jan 20, 2018·Physiological Reviews·Alexei Verkhratsky, Maiken Nedergaard
Nov 22, 2016·Journal of Neuroscience Research·Bruce S McEwen, Teresa A Milner
May 10, 2018·Frontiers in Endocrinology·Yasushi Hojo, Suguru Kawato
Jan 10, 2021·Neuroscience Letters·Jaideep Kapur, Suchitra Joshi
Nov 7, 2017·Steroids·Derek A SchreihoferRebecca L Cunningham
Jul 23, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoyan ZhuRachida Guennoun
Dec 31, 2017·Frontiers in Neuroendocrinology·Jennifer R RainvilleGeorgia E Hodes
Jun 18, 2021·Cellular and Molecular Neurobiology·Alejandro F De NicolaMaria Claudia Gonzalez Deniselle
Jun 25, 2021·Epilepsia·Shinnosuke ShionoSuchitra Joshi

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