PMID: 45929Jan 1, 1975

Ultrastructural localization of in vivo bound immunoglobulins in bullous pemphigoid--a preliminary report

The Journal of Investigative Dermatology
G Schaumburg-LeverW F Lever

Abstract

The ultrastructural location of in vivo bound immunoglobulins in a case of bullous pemphigoid was determined by coupling peroxidase to antihuman gamma globulin. Immunoglobulin deposits were found exclusively in the space between the basal cells and the basal lamina. The location of the immunoglobulin in bullous pemphigoid thus differs from that in lupus erythematosus where immunoglobulins are found mainly below the basal lamina.

References

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Related Concepts

Establishment and Maintenance of Localization
Ovoperoxidase
Immunoglobulin Activity
Peroxidases
Immunoglobulins
Basal Lamina
Gamma globulin
Electron Microscopy
Skin
Lupus Erythematosus, Systemic

Related Feeds

Bullous Pemphigoid

Bullous pemphigoid is a chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis. Discover the latest research on bullous pemphigoid here.

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