PMID: 8938253Feb 9, 1996Paper

Ultrastructural localization of nerve terminals containing nitric oxide synthase in rat adrenal gland

Neuroscience Letters
K Tanaka, T Chiba

Abstract

Immunoelectron microscopy was performed to localize immunoreactivity for nitric oxide synthase (NOS) in rat adrenal gland. NOS-immunoreactive (NOS-ir) nerve fibers were observed around blood vessels and endocrine cells in the zona glomerulosa of the cortex. Electron microscopy showed that NOS-ir axon varicosities were in close contact with the smooth muscles of blood vessels and with the cytolemma of endocrine cells. In the adrenal medulla, several NOS-ir ganglion cells were found. Synaptic contacts between non-immunoreactive axons and dendrites of NOS-ir neurons were observed. NOS-ir nerve fibers were distributed among chromaffin cells. Positive axon varicosities were in close contact with the catecholamine-storing chromaffin cells. These results suggest that NOS-ir nerve cells control directly the secretion of corticosteroid and catecholamine in addition to the vascular tone.

References

Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Feb 28, 1992·Biochemical and Biophysical Research Communications·H OhshimaH Esumi
Jan 7, 1992·European Journal of Pharmacology·M J BreslowR J Traystman
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Mar 2, 1995·Journal of the Autonomic Nervous System·K Tanaka, T Chiba
Sep 3, 1993·Neuroscience Letters·T HanazawaT Chiba

❮ Previous
Next ❯

Citations

Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·Hamzeh H ElayanMichael G Ziegler
Jul 19, 2002·Journal of Neuroscience Research·S VicenteM J Oset-Gasque
Oct 17, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Onoda, H Inano
Mar 20, 2003·Journal of Neuroscience Research·Donghou KimOnyou Hwang
May 25, 2007·Journal of Neuroscience Research·Rocío Pérez-RodríguezMaría J Oset-Gasque
Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·R SalemiE M Wintour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.