PMID: 6409144Jun 7, 1983Paper

Ultrastructural morphology and domain structure of a unique collagenous component of basement membranes

Biochemistry
J A MadriH Furthmayr

Abstract

A disulfide cross-linked collagenous fragment (7 S) has been isolated by pepsin solubilization from several tissues rich in basement membranes including bovine lung, human placenta, and the murine EHS tumor. Examination of this material by the rotary shadowing technique indicates that these fragments are similar to but not identical with the 7S collagen described recently [Risteli, J., Bächinger, H.P., Engel, J., Furthmayr, H., & Timpl, R. (1980) Eur. J. Biochem. 108, 239-250]. The central rodlike portion of the particles was found to be similar in length; however, the peripheral four arms of 7S particles from bovine and murine sources are 10 nm longer in comparison to those from human sources. In addition, about 5-7% of all the particles contain a fifth arm. Specific antibodies to bovine 7 S cross-react with murine 7 S but only to a rather limited extent with human 7 S. These antibodies react with antigenic sites located at the ends of the peripheral arms of the fragment as visualized directly with rotary shadowing techniques. The data are consistent with a structural difference in type IV collagens from bovine, human, and mouse which leads to pepsin cleavage at different sites in a particular noncollagenous region adjacent to...Continue Reading

Citations

Aug 1, 1987·The American Review of Respiratory Disease·E C Crouch, D Chang
Jan 1, 1984·Connective Tissue Research·S N DixitA H Kang
Jan 31, 2006·BMC Veterinary Research·Mikael NikuAntti Iivanainen
Apr 1, 1989·The Anatomical Record·P R Brauer, J M Keller

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