PMID: 15374314Jan 1, 1994Paper

Ultrastructural morphometric analysis of lipofuscin in pyramidal cells of the human Ammon's horn

Archives of Gerontology and Geriatrics
D R Thal, W Schlote

Abstract

Lipofuscin is a waste product of autolysosomal metabolism. The amount of lipofuscin in the cytoplasm depends on cell type, cell function and age. In most studies, either the fluorescent or the stained component of lipofuscin was investigated. Quantitative morphological investigations of the lipofuscin composition separated into the vacuolar and granular component were missing. For the hippocampal pyramidal cells we have determined the lipofuscin quantity and, separately, the vacuolar and granular component at the ultrastructural level. The hippocampal subfields CA 1, CA 2, CA 3 and CA 4 were observed at the ages 20, 40, 60 and 80 years (+/-3 years). Quantitative determinations of the vacuolar and granular component of neuronal lipofuscin in pyramidal cells were performed with a semi-automatic image analysis system. In CA 1 pyramidal cells the lipofuscin content was significantly lower than in the other sectors, which did not differ significantly in their lipofuscin content. The amount of the granular component in relation to the vacuolar component in CA 1 was larger than in the other sectors. With advancing age the lipofuscin content per cell increased. The vacuolar component of all hippocampal subfields experienced a larger in...Continue Reading

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Citations

Mar 31, 1995·Mechanisms of Ageing and Development·D R Thal, W Schlote
Jul 9, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Chikako KawaguchiYukito Shinohara
Apr 9, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Terman, U T Brunk
Nov 10, 2015·Ultrastructural Pathology·Suélen MerloJorge E Moreira
May 5, 2009·Neurobiology of Aging·Marco AssunçãoJosé P Andrade

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