PMID: 9192549Jan 1, 1997Paper

Ultrastructural morphometry of parotid acinar cells following fractionated irradiation

Oral Oncology
A L GrehnR Henriksson

Abstract

The aim of this study was to evaluate the long term effects on the ultrastructure of parotid glands after fractionated irradiation. The method implemented involved 5 x 6 Gy and 5 x 8 Gy, Monday to Friday 6 MV photons. By unilateral irradiation, the contralateral parotid gland served as a control. Although irradiation diminished the acinar cell density in light microscopic sections from 75 to 32% after 5 x 8 Gy of irradiation, ultrastructural morphometry could not detect any statistically significant differences in acinar cell size, nuclear size, nuclear density, granule area, mean granule size, or granule density. In general, greater differences were seen between rats receiving 30 or 40 Gy, on both the irradiated and the control size, than between the irradiated side and the control side. This was interpreted as due to differences in the nutritional state of the animals. This analysis concluded that individual acinar cells that survive irradiation seem not to be damaged in the long term when evaluated at the ultrastructural level. The study further stresses the importance of adequate sampling sizes and the use of adequate controls.

References

Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K AbokJ Ericsson
Apr 1, 1980·International Journal of Radiation Oncology, Biology, Physics·N E PrattM Sinesi

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Citations

Oct 1, 2010·Journal of Oral Science·Fabrício M TujiFrab N Bóscolo
Jan 14, 2012·Dento Maxillo Facial Radiology·M ImanimoghaddamF Homaeieshandiz
Apr 23, 2011·The British Journal of Radiology·S C H ChengM T C Ying
Feb 3, 2016·The British Journal of Oral & Maxillofacial Surgery·Pia Lopez-JornetVicente Vicente-Ortega
May 1, 2007·Ultrasound in Medicine & Biology·Michael YingDora L W Kwong
Aug 24, 2013·Brazilian Dental Journal·Carolina Cintra GomesSolange Maria de Almeida
Jun 1, 2007·Journal of Applied Oral Science : Revista FOB·Maria Luiza dos Anjos PontualSolange Maria de Almeida
Nov 14, 2020·International Journal of Molecular Sciences·Ji-Youn KimJae-Kwang Jung

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