PMID: 9532002Apr 9, 1998Paper

Ultrastructural pathology of the alveolar type II pneumocytes of human donor lungs. Electron microscopy, stereology, and microanalysis

Virchows Archiv : an International Journal of Pathology
H FehrenbachJ Richter

Abstract

Alveolar type II pneumocytes (PII) were studied in 12 human donor lungs perfused with modified Euro-Collins solution during single-lung transplantation (SLTx). While one lung was transplanted, the contralateral donor lung (cDL) was fixed at the time of SLTx for examination by electron microscopy, stereology, and microanalysis. Three groups were then formed: group A (n = 7), cDL without contusions, uneventful early postoperative course; group B (n = 3), cDL with conclusions, uneventful early postoperative course; group C (n = 2), cDL without contusions, early postoperative respiratory dysfunction. The major findings were that the presence of contusions had no effect on PII ultrastructure and that intracellular surfactant-storing lamellar bodies of cDL in group C were characterized by a higher volume-to-surface ratio (VsR) and larger area per cell profile than group A. Correlation analysis based on pooled data (groups A and C) showed that ischaemic time had little effect on PII ultrastructure and bore no relationship to postoperative clinical variables. The duration of preoperative donor intubation had a pronounced influence on ultrastructure and postoperative clinical variables. The stereologically estimated amount of intracellu...Continue Reading

Citations

Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Antonia FehrenbachJoachim Richter
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T WittwerJ Richter
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·M OchsH Fehrenbach
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·Kai NowakMartha-Maria Gebhard
Sep 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Frank BraschMatthias Ochs
Jul 1, 2011·Expert Opinion on Medical Diagnostics·Lars Knudsen, Matthias Ochs
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus KamlerHeinz Jakob
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Matthias OchsJoachim Richter
May 27, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Scott MilosRuud Veldhuizen
May 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars P LundingMichael Wegmann
Oct 15, 2020·Histochemistry and Cell Biology·Lars KnudsenMatthias Ochs

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