Ultrastructural studies of IgG4-related kidney disease

Internal Medicine
Shinichi NishiTakako Saeki

Abstract

Ultrastructural studies of IgG4-related kidney disease (IgG4-RKD) characterized by tubulointerstitial nephritis (TIN) are limited in previous reports due to the rarity of the condition. In the present report, we performed ultrastructural examinations and assessed the pathogenesis of this disease. Clinicopathological studies were conducted in eight patients diagnosed with IgG4-RKD. Routine light, immunofluorescence and electron microscopy examinations and immunohistochemical assessments of IgG4 were performed using renal biopsy samples. Hypocomplementemia, positive anti-nuclear antibodies and eosinophilia were confirmed in more than half of the cases. Electron dense deposits (EDDs) were frequently found in the glomeruli and interstitium. The rate of deposition was 62.5% in both mesangial areas and Bowman's capsule. EDDs were frequently detected on the tubular basement membrane (TBM) (87.5% of patients). The interstitium also contained EDDs on collagen fibers in 87.5% of the cases and on basement membrane-like materials in areas of fibrosis in 37.5% of the cases. The creatinine clearance levels were significantly lower in the patients with the latter pattern. Meanwhile, the rate of immunoglobulin and/or complement deposition on t...Continue Reading

References

Dec 5, 2002·Clinical Transplantation·Satoshi ShiozawaHidekazu Shigematsu
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shin-ichi TakedaEisuke Takazakura
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoko Uchiyama-TanakaToshiji Iwasaka
Apr 15, 2005·Clinical and Experimental Nephrology·Yasukiyo MoriToshiji Iwasaka
Oct 26, 2006·The American Journal of Surgical Pathology·Simon J W WatsonChristopher O S Bellamy
Jun 27, 2007·Clinical and Experimental Nephrology·Takako SaekiFumitake Gejyo
Sep 11, 2007·Internal Medicine·Takako SaekiFumitake Gejyo
Sep 27, 2007·The American Journal of Surgical Pathology·Lynn D CornellRobert B Colvin
Jul 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeGregory Y Lauwers
Dec 2, 2009·The American Journal of Surgical Pathology·Yoh ZenYasuni Nakanuma
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Yassaman RaissianLynn D Cornell
Aug 27, 2011·Clinical and Experimental Nephrology·Shinichi NishiTakako Saeki
Sep 6, 2011·Human Pathology·Yutaka YamaguchiUNKNOWN Japanese study group on IgG4-related nephropathy
Sep 8, 2011·Clinical and Experimental Nephrology·Mitsuhiro KawanoTakao Saito
Jan 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kazuhiro YoshitaTakako Saeki
Aug 18, 2012·International Journal of Rheumatology·Mitsuhiro KawanoTakako Saeki
Oct 11, 2013·Kidney International·Takako Saeki, Mitsuhiro Kawano

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Citations

Apr 4, 2019·Fetal and Pediatric Pathology·Secil Arslansoyu CamlarSalih Kavukcu
Aug 29, 2019·Journal of Dental Research·X HongH Y Yang
Jan 24, 2018·World Journal of Nephrology·Maurizio Salvadori, Aris Tsalouchos
Apr 20, 2021·Frontiers in Medicine·Riccardo CapecchiPaola Migliorini

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