PMID: 4895598Sep 1, 1969Paper

Ultrastructural studies of radiation-induced chromosome damage

The Journal of Cell Biology
R M Humphrey, B R Brinkley

Abstract

The fine structure of radiation-induced chromosomal aberrations in Potorous tridactylis (rat kangaroo) cells was examined in situ by electron microscopy. The observations on the structure of terminal deletions (acentric fragments), anaphase bridges and "gaps," sidearm bridges, and specialized regions, such as the nucleolus organizer, are discussed in detail. Conclusions based on these observations are the following: (a) damage is physically expressed only at anaphase; (b) a gap region is composed of two subunits, each of which is about 800-1000 A in diameter and may correspond to a half-chromatid structure; (c) the ends of acentric fragments are structurally similar to normal chromosome ends, except where the break occurs in a specific region such as the secondary constriction; (d) at metaphase the fragment and the main portion of the chromosome move as a single unit to the equator, and the two units are disconnected only at the onset of anaphase; (e) sidearm bridges appear to be exchanges, involving a subchromatid unit. The interpretation of this evidence is consistent with the hypothesis that the chromosome is a multistranded structure.

References

Aug 1, 1965·The Journal of Cell Biology·T C HsuB R Brinkley
Oct 1, 1967·The Journal of Cell Biology·B R BrinkleyL C Richardson
Jan 1, 1966·Chromosoma·B R Brinkley, E Stubblefield
Mar 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·T C HSU, C E SOMERS
Jun 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·C E SOMERS, T C HSU
Apr 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·B HAMPAR, S A ELLISON

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Citations

Mar 1, 1974·Mutation Research·K M FisherT E Everhart
Dec 10, 1999·Micron : the International Research and Review Journal for Microscopy·Z Somosy
Dec 1, 1973·Environmental Health Perspectives·W W Nichols
Feb 1, 1977·Mutation Research·S Brecher
Dec 1, 1975·Experimental Cell Research·S Brecher
Apr 1, 1985·Experimental Cell Research·S TakayamaH Kitasumi
Oct 13, 2015·Journal of Environmental Sciences (China)·Jaqueline BianchiMaria Aparecida Marin-Morales
Jan 1, 1977·Applied Optics·J Eichler, H Lenz
Jul 2, 2019·Genetics and Molecular Biology·Ronaldo Dos Santos FilhoDaniela Morais Leme
Jul 28, 2020·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Brandt Warecki, William Sullivan
Jun 17, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·N C GhisiE C Oliveira

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