Ultrastructural studies of the bone marrow in sickle cell anaemia. I. The structure of sickled erythrocytes and reticulocytes and their phagocytic destruction

British Journal of Haematology
J A GrassoL W Sullivan

Abstract

Marrow aspirates from sickle cell patients were examined without prior deoxygenation and revealed the presence of a variable proportion (10-30%) of sickled red cells and reticulocytes. The main feature of sickled red cells was the presence of 17.6 nm fibres arranged in hexagonal order, and to a lesser extent in square or rectangular array, to form bundles of varying size and compactness which occupied the entire cytoplasm. The sickling pattern in reticulocytes was more variable. Some reticulocytes contained highly-ordered bundles of 17.6 nm fibres whose structure and distribution was identical to that in red cells from whiich they could be distinguished only by their content of organelles. Many reticulocytes exhibited less-organized fibre patterns ranging from localized aggregates to poorly-ordered regions of short fibres and filaments lacking apparent preferential orientation. In these cells, the bulk of the cytoplasm was not polymerized. Haemoglobin polymerization in reticulocytes led to entrapment of ribosomes in concentrated foci among the fibres. Frequently, iron-laden mitochondria were associated with sickled reticulocytes. The variation in pattern of sickling seen in reticulocytes is attributed to possible differences in...Continue Reading

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Citations

Dec 1, 1976·British Journal of Haematology·J A HahnT B Bradley
Jan 5, 2011·Haematologica·Matthew M HsiehJohn F Tisdale
May 31, 2014·Oxidative Medicine and Cellular Longevity·Giovanni PaganoAdriana Zatterale
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Jun 7, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Saratchandra Singh Khumukcham, Bramanandam Manavathi

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