Ultrastructural studies on cerebrovascular permeability in acute hypertension.

Acta Neuropathologica
H A HanssonC Blomstrand

Abstract

Acute hypertension, experimentally induced by intravenous injection of metaraminol in adult rabbits, rapidly induced a damage of the blood-brain barrier in the cerebral cortex, as visualized by Evans-blue-conjugated albumin and horseradish peroxidase. Extravasation of these two exogenous tracers was demonstrated to occur in arterioles, in capillaries and, rarely, in venules. Peroxidase passed the endothelial cell into the nervous tissue in either or three different ways, i.e. through channels, often sigmoidshaped, in the cytoplasm, and transendothelial pinocytosis. The third pathway could, although rarely, be demonstrated between adjacent endothelial cells after cleavage of junctional complexes. The tracer peroxidase was further spread along the blood vessel within the basement membrane and in the extracellular space of the brain. Damaged endothelial cells with diffuse cytoplasmic peroxidase activity and large vesicles were occasionally observed within the areas with blood-brain barrier injury. There were also signs of increased pinocytotic activity in endothelial cells outside the barrier damaged cortical areas. Nerve cells and neuroglial cells could show either a diffuse cytoplasmic peroxidase activity or a vesicular location...Continue Reading

References

Jan 1, 1970·Acta Neuropathologica·Y Olsson, K A Hossmann
Oct 1, 1966·Journal of Neuropathology and Experimental Neurology·O Steinwall, I Klatzo
Jan 1, 1973·Acta Neurologica Scandinavica·K Onoyama, T Omae
Jun 1, 1971·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T EtoT Yamamoto
Jun 7, 1968·Acta Neuropathologica·P C KungL Bakay
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky

❮ Previous
Next ❯

Citations

Apr 12, 1979·Acta Neuropathologica·S NagH B Dinsdale
Apr 1, 1986·Journal of Neurosurgery·S HatashitaS Ishii
Aug 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S NagH B Dinsdale
Jan 31, 1979·Pflügers Archiv : European journal of physiology·E T MacKenzieA M Harper
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R P SimonJ Bronstein
Aug 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J RaymondH B Dinsdale
Jan 1, 1984·Cancer Drug Delivery·M K SpigelmanJ F Holland
Jul 1, 1983·Stroke; a Journal of Cerebral Circulation·M TagamiY Yamori
Jun 16, 2004·The International Journal of Neuroscience·A Nukhet Turkel, Y Ziya Ziylan
May 1, 1983·Annals of Neurology·L Junck, W H Marshall
Nov 1, 1990·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D J ColeB I Chi-Lum
Mar 1, 1980·Stroke; a Journal of Cerebral Circulation·L AuerE T MacKenzie
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·M TagamiY Yamori
Mar 1, 1984·Journal of Neurosurgery·P A TornheimR L McLaurin
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Jul 23, 2005·Endothelium : Journal of Endothelial Cell Research·Marilyn J CipollaErica Hammer
Mar 1, 1980·Acta Physiologica Scandinavica·J E Hardebo, C Owman
Jan 1, 1980·Journal of Neuroscience Research·H A Hansson, B B Johansson
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·T G Bolwig
Nov 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J RaymondS Nag
Mar 1, 1982·Stroke; a Journal of Cerebral Circulation·B B JohanssonL E Linder
Sep 4, 2015·BMC Neurology·Marcos C B OliveiraLuiz H Castro
Nov 22, 2017·Journal of Cerebrovascular and Endovascular Neurosurgery·Jun Chul ParkJoon Ho Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.