Ultrastructural studies on peptides in the dorsal horn of the rat spinal cord--II. Co-existence of galanin with other peptides in local neurons

Neuroscience
X ZhangT Hökfelt

Abstract

Using light microscopic immunoperoxidase and immunofluorescence histochemistry, double-staining methodology, and electron microscopic pre-embedding and post-embedding immunocytochemistry, we studied galanin-immunoreactive neurons in the superficial dorsal horn of the rat spinal cord. Co-existence of galanin with other neuropeptides was also analysed. The lumbar 4 and 5 segments of normal rats and after rhizotomy or spinal cord transection were studied. Galanin-positive local neurons in lamina II were often islet cells and could be classified as type A, which had abundant electron-dense cytoplasm containing many large dense-core vesicles, and type B, which had electron-lucent cytoplasm with only a few large dense-core vesicles. Galanin-positive and -negative peripheral afferent terminals made synaptic contact mostly with galanin-negative dendrites and cell bodies, but also with type B galanin cell bodies and with galanin-positive dendrites of unidentified type. Galanin-immunoreactive terminals from local neurons could also be classified into two types. Type alpha terminals were most common; they contained densely packed synaptic vesicles and many large dense-core vesicles, were strongly immunostained and most frequently made syn...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A W MudgeG D Fischbach
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
Oct 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W G ForssmannJ Triepel
Feb 15, 1979·European Journal of Pharmacology·B V ClineschmidtP B Bunting
Sep 28, 1992·Neuroscience Letters·A J Todd, R C Spike
Aug 1, 1985·Brain Research Bulletin·G Skofitsch, D M Jacobowitz
Jun 22, 1986·The Journal of Comparative Neurology·T MelanderA Rökaeus
Jan 1, 1986·Experimental Brain Research·M Herrera-MarschitzU Ungerstedt
Oct 8, 1986·Neuroscience Letters·M YanagisawaN Yanaihara
Apr 1, 1988·Acta Physiologica Scandinavica·C PostT Hökfelt
May 1, 1989·Brain Research. Molecular Brain Research·K NoguchiM Tohyama

❮ Previous
Next ❯

Citations

Aug 27, 1996·Regulatory Peptides·Z Wiesenfeld-Hallin, X J Xu
Mar 3, 1995·Neuroscience Letters·D R SimmonsA J Todd
Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Oct 9, 2002·Trends in Pharmacological Sciences·Hong-Xiang Liu, Tomas Hökfelt
Apr 12, 2002·Progress in Neurobiology·A Merighi
Feb 3, 1999·Annals of the New York Academy of Sciences·D WynickV Pachnis
Feb 3, 1999·Annals of the New York Academy of Sciences·Z Wiesenfeld-Hallin, X J Xu
Jul 30, 2015·Expert Opinion on Therapeutic Targets·Krista FreimannÜlo Langel
Jun 7, 2011·General and Comparative Endocrinology·M A Rodríguez DíazI Rodríguez-Moldes
Sep 17, 2013·Urology·Masashi HondaAtsushi Takenaka
Aug 13, 2021·The Journal of Comparative Neurology·Camila Oliveira MirandaMiklós Antal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.