PMID: 9432338Feb 12, 1998Paper

Ultrastructural study of antral G cells in patients with duodenal ulcer: effect of Helicobacter pylori eradication

Helicobacter
M SugamataM Miura

Abstract

It is established now that Helicobacter pylori infection is associated with exaggerated gastrin release to meals and other stimuli and that the abnormal secretion of gastrin is reversed after successful treatment of the infection. By comparing morphology of G cells from the same patients before and after treatment, we were able to investigate the ultrastructural effect of cure of H. pylori on G cells. Gastric mucosal biopsy specimens were obtained from 10 patients with duodenal ulcer before and 3, 6, and 9 months after cure of H. pylori infection. Negative controls consisted of four healthy volunteers without H. pylori infection. G cells were evaluated by immunohistochemical and electron microscopy. Treatment with H2-antagonists was continued for 6 months after cure of the H. pylori infection. Ultrastructural studies of secretory granules of antral G cells in controls displayed a broad range of electron density ranging from dark with a full appearance to totally electron-lucent with a "vacuolating" appearance. In duodenal ulcer patients before treatment, electron-lucent vacuolating granules predominated. After elimination of H. pylori, G-cell granules showed a marked increase in electron density close to that of controls. Our s...Continue Reading

References

Aug 19, 1985·The Medical Journal of Australia·J R LambertK J Pinkard
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·W G Forssmann, L Orci
May 12, 1984·Lancet·C A McNulty, D M Watson
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Citations

Apr 17, 2004·Journal of Gastroenterology and Hepatology·Alexander A Nijevitch, Peter L Shcherbakov
Oct 7, 2000·Journal of Gastroenterology and Hepatology·K GohS Chin
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Frank J BranickiJohn Wong
Jul 15, 2005·World Journal of Gastroenterology : WJG·Aleksandra Sokic-MilutinovicOlivera Mitrovic

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