PMID: 9183695Jun 9, 1997Paper

Ultrastructural study of cholinergic and noncholinergic neurons in the pars compacta of the rat pedunculopontine tegmental nucleus

The Journal of Comparative Neurology
T L SteiningerD B Rye

Abstract

A group of medium-to-large cholinergic neurons situated in the dorsolateral mesopontine tegmentum comprises the pedunculopontine tegmental nucleus (PPT). The PPT pars compacta (PPT-pc), which occupies the lateral part of the caudal two-thirds of the nucleus, contains a dense aggregation of cholinergic neurons. In the present study, we have employed immunohistochemistry for choline acetyltransferase (ChAT) and electron microscopy to investigate the ultrastructure and synaptic organization of neuronal elements in the PPT-pc. Our results demonstrate that: (1) ChAT-immunoreactive (i.e., cholinergic) PPT-pc neurons are characterized by abundant cytoplasm and organelles, and have few axosomatic synapses (both asymmetric and symmetric); (2) ChAT-immunoreactive dendrites comprise 6-15% of total dendritic elements in the neuropil; the mean percentage of dendritic membrane covered by synaptic terminals is approximately 15%, and nearly all synapses with ChAT-immunoreactive dendrites are asymmetric; (3) within the boundaries described by cholinergic PPT-pc, there are noncholinergic neurons which, in contrast, exhibit a lucent cytoplasm and a higher frequency of axosomatic synapses (10.5% versus 3.7% for cholinergic neurons); and (4) noncho...Continue Reading

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Citations

Dec 19, 2006·Neuroscience Letters·Irma Rukhadze, Leszek Kubin
Sep 24, 2004·The European Journal of Neuroscience·James A AingePhilip Winn
May 22, 2009·The Journal of Comparative Neurology·J Mena-SegoviaJ P Bolam
Aug 20, 2003·The European Journal of Neuroscience·Kazuya SaitohKaoru Takakusaki
Jun 19, 2013·Experimental Neurology·Ilse S Pienaar, Wilma van de Berg
May 21, 2015·Brain Structure & Function·Joanna L ElsonIlse S Pienaar
Jan 1, 2013·ISRN Neuroscience·Kristi A Kohlmeier
Dec 23, 1999·Current Opinion in Neurobiology·S T KitaiR Scroggs
Oct 12, 2005·The Journal of Comparative Neurology·Carolina CebriánLucía Prensa
Mar 31, 2011·Journal of Neural Transmission·Erlick A C PereiraTipu Z Aziz

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