PMID: 9174632May 1, 1997Paper

Ultrastructural study of human herpesvirus-7 replication in tissue culture

Virchows Archiv : an International Journal of Pathology
J P KlussmannG R Krueger

Abstract

Human herpesvirus 7 (HHV-7) was grown in a CD4+ lymphoblastic cell line (SupT1) and in cord blood mononuclear cells (CBMC). Virus infection was demonstrated by immunohistology with positive control sera, with monoclonal antibodies and by in situ hybridization for viral DNA. Cytopathic effects following HHV-7 infection generally resemble those after HHV-6 infection but are less pronounced. The ultrastructural appearance of HHV-7 and the replicative stages were similar to those described by Kramarsky and Sander for HHV-6. There were some minor discrepancies, including quite an extensive and space-filling tegument, a slightly different structure of the nucleoid, the frequent finding of nucleocapsids without any visible core and apparently scarce or delicate spikes on the envelope. These differences may suggest HHV-7 rather than HHV-6, but this finding needs confirmation. Mature HHV-7 particles measured 170 nm in diameter, with nucleocapsids of 90-95 nm and a tegument of about 30 nm.

Citations

Dec 1, 1999·Reviews in Medical Virology·J B Black, P E Pellett
Oct 3, 2001·Journal of Virology·Y ZhangD Schols
Apr 21, 2005·Avian Diseases·Gui-ping YuanChao Xu
Feb 26, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alfonso Escobar-VillalbaIñigo Corral
Apr 1, 2010·Orvosi hetilap·József OngrádiEniko Kováts
Oct 25, 2016·Seminars in Nephrology·Carlos A Q Santos

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