PMID: 2493181Jan 1, 1989Paper

Ultrastructural study of melanocytic lesions in albino guinea pigs induced with 7,12-dimethyl-benzanthracene

Ultrastructural Pathology
V Vicente, S Gómez

Abstract

We studied the fine structure of benign, premalignant and malignant melanocytic lesions induced in Dunkin-Hartley guinea pigs by means of topical application of 7,12-dimethyl-benzanthracene (DMBA). The most noteworthy characteristics of the atypical melanocytes (melanocytic dysplasia and melanomas) were the variable morphology and structure, and, in particular, the aberrant character of the melanosomes. The melanocytes presented irregularity of nuclear outlines with frequent lobulation. The heterochromatin was usually found in thick clumps reinforcing the nuclear membrane, and the nucleoli were usually multiple. The melanosomes were ellipsoidal and spherical with a pattern that was lamellar, concentric, incomplete, and even microgranular and microvesicular. The melanization was usually in thick, irregular clumps. Melanosome complexes were always present.

References

Mar 1, 1978·The British Journal of Dermatology·J A HunterA J Cochran
Nov 1, 1976·Archives of Ophthalmology·F E O'DonnellD L Stone
Jun 1, 1987·The American Journal of Dermatopathology·H TakahashiK Jimbow
Nov 1, 1973·The Journal of Investigative Dermatology·K JimbowT B Fitzpatrick
Apr 1, 1973·Journal of Ultrastructure Research·V J HearingM A Lutzner
Aug 1, 1982·Journal of Cutaneous Pathology·J H BurgessS Lantis
May 1, 1980·Histopathology·A Garner, B S Jay

❮ Previous
Next ❯

Citations

Aug 1, 1995·Pigment Cell Research·J Garcia GonzalezJ Rodriguez Vicente

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pigment Cell Research
S GómezA Hernandez-Gil
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Miguel Angel PérezMaría Elina Itoiz
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Xiao-Han TangLorraine J Gudas
© 2022 Meta ULC. All rights reserved