PMID: 6414233Jan 1, 1983Paper

Ultrastructural study on nervous system of fetus with GM1-gangliosidosis type 1

Acta Neuropathologica
T YamanoS Kanda

Abstract

The nervous system of a 22-year-old fetus with GM1-gangliosidosis type 1 was studied by electron microscopy. The tissues thus examined were the cerebral cortex at the parietal region, the cerebellum, the thoracic spinal cord, the Auerbach's myenteric plexus in the large intestine and the radial nerve fibers. In the cerebral cortex, membrane-bound vacuoles, which occasionally contained stacks of fine fibrils, were observed in the large young neurons in the deeper part of the cortical plate. The neurons in the other part of the cerebral cortex carried no storage materials. In the cerebellum, the membrane-bound vacuoles with stacks of fine fibrils were seen only in the Purkinje cells. The neurons in the spinal cord also contained several zebra-like bodies and the above membrane-bound vacuoles. As for the peripheral nervous system (PNS), neurons in the Auerbach's myenteric plexus carried membranous cytoplasmic bodies and zebra-like bodies. Some of the axons in the radial nerve fibers also contained a lot of pleomorphic electron-dense bodies and a few membranous cytoplasmic ones. These results show that the accumulation of storage materials is started in the large neurons which are produced in the early stage of neurogenesis in the ...Continue Reading

References

Jul 1, 1976·Pediatric Research·K AbeM Ishikawa
Mar 21, 1970·Lancet·L SchneckB W Volk
Jan 1, 1969·Journal of Neuropathology and Experimental Neurology·K Suzuki, S Kamoshita
Aug 1, 1969·The Journal of Pediatrics·J O'Brien
Feb 1, 1973·The New England Journal of Medicine·J A LowdenT A Doran
Jun 1, 1973·Archives of Neurology·A K PercyR M Herndon
Jun 1, 1973·The Journal of Pediatrics·M M KabackA K Percy
Dec 1, 1973·American Journal of Ophthalmology·M J WeissE Cotlier
Dec 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·B W VolkC Valenti
Apr 1, 1968·Journal of Neuropathology and Experimental Neurology·P Rakic, R L Sidman
May 31, 1968·Science·S Okada, J S O'Brien
May 1, 1980·Pediatric Research·U N WiesmannN Herschkowitz
Nov 1, 1982·Journal of Neuropathology and Experimental Neurology·M RodriguezH C Powell

❮ Previous
Next ❯

Citations

Jan 1, 1986·Acta Neuropathologica·T YamanoH Yabuuchi
Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A Schmitt-Gräff
Feb 20, 2015·ASN Neuro·Karie A HeineckeThomas N Seyfried
Jan 1, 1993·Antonie van Leeuwenhoek·T Beppu
Apr 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuefang PanAlexey V Pshezhetsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.