Jan 1, 1988

Ultrastructure and some biological properties of influenza A virus. IV. Effect of proteolytic enzymes on viral particle

Archivum Immunologiae Et Therapiae Experimentalis
M Chomik, A Slusarczyk


Influenza virus strain A/USSR/053/74/H3N2 was subjected to the effect of soluble and nonsoluble trypsin. Both enzymes appeared to affect the activity of neuraminidase. The viruses altered in this way did not induce interferon (IFN) in mice. Treatment of viral particles with soluble bromeline brought about almost complete inactivation of hemagglutinin and slight suppression of neuraminidase activity. This virus was capable of IFN induction. On the other hand, when nonsoluble bromeline was used as the treatment agent, complete inactivation of neuraminidase and reduction of hemagglutinin titer were observed. This virus was not capable of IFN induction. Viral preparations treated with pronase, trypsin and bromeline for a total extraction of the surface antigens, did not induce IFN. The viruses treated with these enzymes were examined under the electron microscope. Trypsin-treated viruses showed no changes on their surface while bromeline and pronase totally extracted the spikes of surface antigens.

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Mentioned in this Paper

Exo-alpha-sialidase Activity
Enzymes, antithrombotic
Peptide Hydrolases
Human leukocyte interferon
Proteolytic enzymes for treatment of wounds and ulcers

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