Ultrastructure of calcitonin gene-related peptide- and substance P-like immunoreactive nerve fibres in the carotid body and carotid sinus of the guinea pig.

Histochemistry
Wolfgang KummerC Heym

Abstract

Previous studies have demonstrated that substance P- (SP) and calcitonin gene-related peptide-like immunoreactivities (CGRP-LI) coexist in sensory nerve fibres in the guinea-pig carotid body and carotid sinus. In the present study the ultrastructure of these nerve fibres was investigated by means of single- and double-labelling immunocytochemistry. In both, carotid body and carotid sinus immunoreactive fibres were unmyelinated axons of small diameter (0.12-0.56 microns). At the subcellular level, SP- and CGRP-LI were colocalized in intra-axonal dense core vesicles, suggesting corelease and simultaneous action of these two compounds. SP/CGRP-LI nerve fibres within the carotid body were mainly found in the interparenchymal connective tissue, but also occurred in relationship to blood vessels and nests of glomus cells. Neither in the carotid body not in the carotid sinus, SP/CGRP-LI axons corresponded to the large terminals which are generally considered to represent the main chemoreceptor and baroreceptor endings, respectively. Thus, SP/CGRP-LI fibres either belong to the chemo- and baroreceptors of the C-fibre class or constitute a fibre population not directly involved in conduction of baro- and chemoreflexes.

References

Jul 1, 1977·The Anatomical Record·W G ForssmannD W Fawcett
Jul 20, 1976·Cell and Tissue Research·P Böck, K Gorgas
Dec 1, 1987·The Journal of Physiology·H M ColeridgeH D Schultz
Jul 1, 1971·Physiological Reviews·T J Biscoe
Dec 1, 1971·Journal of Ultrastructure Research·H Kondo
Dec 1, 1969·The Journal of Physiology·S J Fidone, A Sato
Mar 1, 1980·Brain Research Bulletin·D M Jacobowitz, C J Helke
May 1, 1980·The Journal of Physiology·D S McQueen
Jul 1, 1984·Acta Physiologica Scandinavica·N R PrabhakarC von Euler
Oct 1, 1982·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·T J Biscoe, D J Pallot
Dec 1, 1980·Journal of Neurophysiology·Y HayashidaC Eyzaguirre

❮ Previous
Next ❯

Citations

Jan 1, 1991·The American Journal of Anatomy·D S KnightJ A Beal
Jun 10, 2006·Cellular and Molecular Neurobiology·Patrícia Aline Boer, José Antonio Rocha Gontijo
Oct 15, 1993·The Journal of Comparative Neurology·Z Z WangL J Stensaas
Jul 15, 1994·The Journal of Comparative Neurology·A DahlqvistS Forsgren
Aug 1, 1997·Acta Odontologica Scandinavica·I Fristad
Nov 17, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daryl O SchwenkePatricia A Cragg
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
Oct 18, 2002·Microscopy Research and Technique·Hiroyuki Ichikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.