Ultrastructure of cardiac muscle in reptiles and birds: optimizing and/or reducing the probability of transmission between calcium release units.

Journal of Muscle Research and Cell Motility
Stefano PerniC Franzini-Armstrong

Abstract

It is known that cardiac myocytes contain three categories of calcium release units (CRUs) all bearing arrays of RyR2: peripheral couplings, constituted of an association of the junctional SR (jSR) with the plasmalemma; dyads, associations between jSR and T tubules; internal extended junctional jSR (EjSR)/corbular jSR that is not associated with plasmalemma/T tubules. The bird hearts, even if fast beating (e.g., in finch and hummingbird) have no T tubules, despite fiber sizes comparable to those of mammalian ventricle, but are rich in EjSR/corbular SR. The heart of small lizard also lacks T tubule, but it has only peripheral couplings and compensates for lack of internal CRUs by the small diameter of its cells. We have extended previous information on chicken heart to finch and lizard by establishing a spatial relationship between RyR2 clusters in jSR of peripheral couplings and clusters of intra-membrane particles identifiable as voltage sensitive calcium channels (CaV1.2) in the adjacent plasmalemma. This provides the structural basis for initiation of the heart beat in all three species. Further we evaluated the distances separating peripheral couplings from each other and between EjSR/corbular SR sites within the bird muscl...Continue Reading

References

Jan 1, 1978·Tissue & Cell·E H BossenR A Waugh
Aug 1, 1992·Biophysical Journal·M D Stern
Oct 1, 1974·The Journal of Cell Biology·R A Waugh, J R Sommer
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·R M Santer, J L Cobb
Dec 1, 1971·The American Journal of Anatomy·R Hirakow
Sep 1, 1970·The Journal of Cell Biology·K M Baldwin
May 1, 1984·Journal of Ultrastructure Research·P C Dolber, J R Sommer
Jan 1, 1984·Tissue & Cell·E H Bossen, J R Sommer
May 1, 1995·The Journal of Cell Biology·X H SunC Franzini-Armstrong
Jan 10, 1996·Developmental Biology·F ProtasiC Franzini-Armstrong
Dec 22, 1999·Annals of the New York Academy of Sciences·C Franzini-ArmstrongV Ramesh
Dec 22, 1999·Annals of the New York Academy of Sciences·J R SommerI Taylor
Jan 24, 2002·Nature·Donald M Bers
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Feliciano Protasi
Jan 28, 2003·Biophysical Journal·Pierre TijskensClara Franzini-Armstrong
Oct 1, 1960·The Journal of Biophysical and Biochemical Cytology·P M GRIMLEY, G A EDWARDS
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·David BaddeleyChristian Soeller

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Citations

Mar 1, 2019·The Journal of Experimental Biology·Thomas M D SheardHolly A Shiels
Nov 5, 2014·Physiology·Holly A Shiels, Gina L J Galli
Jul 25, 2015·Experimental Physiology·Holly A Shiels, Rebecca Sitsapesan
Aug 28, 2020·The Journal of Experimental Biology·Tatiana S FilatovaHolly A Shiels
Jul 4, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·S H VermijJ P Kucera

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