Ultrastructure of CIC-DUX4 sarcoma: the first pathological report.

Ultrastructural Pathology
Hisashi TamadaHiroyuki Kanno

Abstract

CIC-DUX4 sarcoma (CDS) is a recently identified subtype of small round cell sarcoma. Morphologically, CDS partially resembles Ewing sarcoma (ES) and has been classified as "ES-like sarcoma"; however, detailed clinicopathologic and molecular genetic analyses have indicated that CDS is a new independent disease. Many studies have provided light microscopic, immunohistochemical, and genetic information about CDS. However, ultrastructural findings associated with this sarcoma are lacking. The aim of this study was to investigate the ultrastructure of CDS tumors and to compare their features with those of ES. We examined two cytogenetically confirmed CDS cases. We found that, compared to typical ES, CDS presented heterogeneity: in cell density, from tightly packed to loosely unconnected areas; in cell shape, from polygonal to pleomorphic with small processes; and in nuclear shape including round, oval, polygonal, elongated, invaginated, or wrinkled formations. However, abundant glycogen in the cytoplasm and rare cell adhesion apparatus between cells are major similarities between CDS and typical ES. Neuroendocrine granules, which are seen in rare ES cases, could not be identified in these two CDS cases. Although cytogenetic differen...Continue Reading

References

Apr 24, 2012·Pathology, Research and Practice·Elena MaldiRenzo Boldorini
Nov 13, 2013·Histopathology·Cristina Antonescu
Dec 20, 2015·The American Journal of Surgical Pathology·Akihiko YoshidaAkira Kawai
Mar 28, 2017·The American Journal of Surgical Pathology·Cristina R AntonescuChristopher D Fletcher

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